GRAMD1B
GRAM domain containing 1B
Summary
Predicted to enable cholesterol binding activity; cholesterol transfer activity; and phospholipid binding activity. Predicted to be involved in cellular response to cholesterol; cholesterol homeostasis; and intracellular sterol transport. Located in endoplasmic reticulum membrane; endoplasmic reticulum-plasma membrane contact site; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants55 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs36020612 | 11:123,344,435 | C/T | regulatory region variant | — |
| rs35923643 | 11:123,355,391 | A/G | regulatory region variant | — |
| rs735665 | 11:123,361,397 | G/A | regulatory region variant | — |
| rs184341060 | 11:123,413,479 | G/A | intron variant | — |
| rs760249355 | 11:123,448,094 | C/G | — | uncertain significance |
| rs1478882645 | 11:123,448,197 | C/G | — | uncertain significance |
| rs767530052 | 11:123,448,271 | G/A | — | uncertain significance |
| rs373483380 | 11:123,455,012 | C/T | — | likely benign |
| rs118067934 | 11:123,464,786 | A/G | — | benign |
| rs1951071576 | 11:123,465,484 | C/T | — | likely pathogenic |
| rs780201409 | 11:123,466,702 | G/T | — | uncertain significance |
| rs752857335 | 11:123,474,245 | A/G | — | uncertain significance |
| rs754862708 | 11:123,476,065 | T/C | — | uncertain significance |
| rs114589175 | 11:123,476,108 | T/A | — | benign |
| rs75493628 | 11:123,476,177 | C/T | — | likely benign |
| rs2279519 | 11:123,477,352 | G/A | — | benign |
| rs1380375088 | 11:123,477,356 | G/T | — | uncertain significance |
| rs2497079953 | 11:123,477,369 | A/G | — | uncertain significance |
| rs375511617 | 11:123,477,380 | G/A | — | uncertain significance |
| rs191981781 | 11:123,477,383 | A/G | — | likely benign |
| rs114469707 | 11:123,477,390 | A/G | — | uncertain significance |
| rs377539345 | 11:123,477,450 | A/G | — | uncertain significance |
| rs1952793461 | 11:123,477,458 | G/A | — | uncertain significance |
| rs200540342 | 11:123,479,372 | G/A | — | likely benign |
| rs774227885 | 11:123,479,481 | G/A | — | uncertain significance |
| rs745517263 | 11:123,479,483 | G/A | — | uncertain significance |
| rs1024525756 | 11:123,479,501 | C/T | — | uncertain significance |
| rs371994802 | 11:123,479,502 | G/A | — | uncertain significance |
| rs771808457 | 11:123,479,505 | T/A | — | uncertain significance |
| rs771900117 | 11:123,480,572 | C/T | — | uncertain significance |
| rs374187128 | 11:123,480,899 | C/T | — | likely benign |
| rs10893053 | 11:123,480,981 | T/C | — | benign |
| rs540314980 | 11:123,481,052 | G/A | — | likely benign |
| rs2497232816 | 11:123,483,506 | G/T | — | uncertain significance |
| rs371958694 | 11:123,484,174 | G/A | — | likely benign |
| rs62641672 | 11:123,484,175 | C/G | — | uncertain significance |
| rs369825461 | 11:123,484,181 | C/T | — | uncertain significance |
| rs769863986 | 11:123,484,246 | A/G | — | likely benign |
| rs199604534 | 11:123,484,247 | C/T | — | uncertain significance |
| rs62641671 | 11:123,484,248 | G/A | — | benign |
| rs772035485 | 11:123,484,252 | C/T | — | uncertain significance |
| rs557839467 | 11:123,484,315 | G/C | — | uncertain significance |
| rs1280558584 | 11:123,484,343 | G/A | — | uncertain significance |
| rs732211 | 11:123,485,444 | T/C | — | benign |
| rs149202511 | 11:123,485,466 | G/A | — | likely benign |
| rs375570291 | 11:123,485,482 | G/A | — | uncertain significance |
| rs534553453 | 11:123,485,494 | G/C | — | benign |
| rs374118769 | 11:123,485,511 | C/T | — | likely benign |
| rs770363124 | 11:123,485,512 | G/A | — | uncertain significance |
| rs1349200192 | 11:123,486,195 | G/C | — | — |
| rs375428225 | 11:123,489,414 | G/T | — | uncertain significance |
| rs146845869 | 11:123,493,225 | G/A | — | likely benign |
| rs4083122 | 11:123,493,235 | C/T | — | uncertain significance |
| rs368223750 | 11:123,493,266 | C/G | — | likely benign |
| rs370949646 | 11:123,493,269 | C/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.