rs735665
This is a regulatory region variant variant in the GRAMD1B gene.
▶GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
chronic lymphocytic leukemia
Berndt SI et al. “Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.” Nature Genetics 45(8):868-76 (2013)
Allele A
OR 1.62
p 4.0e-39
N 8,400
Large GWAS
European
Speedy HE et al. “A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.” Nature Genetics 46(1):56-60 (2014)
Allele A
OR 1.64
p 4.0e-24
N 6,938
Large GWAS
European
Slager SL et al. “Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia.” Blood 120(4):843-6 (2012)
Allele A
OR 1.52
p 3.0e-12
N 4,866
Large GWAS
European
Di Bernardo MC et al. “A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia.” Nature Genetics 40(10):1204-10 (2008)
Allele A
OR 1.45
p 4.0e-12
N 1,943
Large GWAS
European
serum IgM amount
Jonsson S et al. “Identification of sequence variants influencing immunoglobulin levels.” Nature Genetics 49(8):1182-1191 (2017)
Allele A
OR 0.15
p 1.0e-23
N 14,442
Large GWAS
European
neoplasm of mature B-cells
Conde L et al. “Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32.” Nature Genetics 42(8):661-4 (2010)
Allele T
OR 1.81
p 4.0e-9
N 1,431
Large GWAS
European
leukemia
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.20
p 8.0e-20
N 449,666
Major Consortium StudyLarge GWAS
European
lymphocyte count
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.03
p 4.0e-13
N 417,277
Major Consortium StudyLarge GWAS
multi-ancestry
About GRAMD1B
Predicted to enable cholesterol binding activity; cholesterol transfer activity; and phospholipid binding activity. Predicted to be involved in cellular response to cholesterol; cholesterol homeostasis; and intracellular sterol transport. Located in endoplasmic reticulum membrane; endoplasmic reticulum-plasma membrane contact site; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
View all GRAMD1B variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
Community Wiki
No community notes yet for this variant. Sign in to start one.
Comments
Sign in to join the discussion.
Loading comments…