rs3749172
This is a protein-altering variant in the GPR35 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
Crohn's disease
Yang SK et al. “Immunochip analysis identification of 6 additional susceptibility loci for Crohn's disease in Koreans.” Inflammatory Bowel Diseases 21(1):1-7 (2015)
Allele A
OR 1.45
p 6.0e-11
N 1,183
Large GWAS
South Asian
About GPR35
Enables C-X-C chemokine receptor activity. Involved in chemokine-mediated signaling pathway; negative regulation of voltage-gated calcium channel activity; and positive regulation of cytosolic calcium ion concentration. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
View all GPR35 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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