GPR35
G protein-coupled receptor 35
Summary
Enables C-X-C chemokine receptor activity. Involved in chemokine-mediated signaling pathway; negative regulation of voltage-gated calcium channel activity; and positive regulation of cytosolic calcium ion concentration. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants52 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs74270181 | 2:241,561,586 | C/T | downstream gene variant | — |
| rs2975780 | 2:241,563,652 | T/G | — | — |
| rs4676410 | 2:241,563,739 | G/C | — | — |
| rs548753085 | 2:241,569,402 | C/T | — | likely benign |
| rs35146537 | 2:241,569,442 | A/G | — | benign |
| rs2536352154 | 2:241,569,446 | A/T | — | uncertain significance |
| rs150808237 | 2:241,569,449 | T/C | — | likely benign |
| rs139197368 | 2:241,569,454 | G/A | — | benign |
| rs1429723308 | 2:241,569,484 | A/G | — | likely benign |
| rs61734451 | 2:241,569,492 | G/C | — | benign |
| rs535196046 | 2:241,569,528 | G/A | — | likely benign |
| rs115880579 | 2:241,569,535 | C/T | — | benign |
| rs552926336 | 2:241,569,557 | C/T | — | uncertain significance |
| rs768727529 | 2:241,569,569 | T/C | — | uncertain significance |
| rs13387859 | 2:241,569,595 | G/A | — | benign |
| rs527604027 | 2:241,569,626 | C/T | — | uncertain significance |
| rs141407998 | 2:241,569,627 | G/A | — | likely benign |
| rs1289052148 | 2:241,569,644 | C/T | — | uncertain significance |
| rs376209708 | 2:241,569,656 | A/T | — | uncertain significance |
| rs147336244 | 2:241,569,669 | G/A | — | likely benign |
| rs369154325 | 2:241,569,681 | C/G | — | uncertain significance |
| rs3749171 | 2:241,569,692 | C/T | missense variant | benign |
| rs201044232 | 2:241,569,703 | G/A | — | uncertain significance |
| rs775602865 | 2:241,569,721 | G/A | — | uncertain significance |
| rs201885896 | 2:241,569,731 | C/T | — | uncertain significance |
| rs547720846 | 2:241,569,736 | C/T | — | uncertain significance |
| rs61734453 | 2:241,569,745 | G/A | — | benign |
| rs368384952 | 2:241,569,770 | C/T | — | uncertain significance |
| rs143712491 | 2:241,569,775 | G/A | — | uncertain significance |
| rs376265458 | 2:241,569,781 | G/A | — | uncertain significance |
| rs34098457 | 2:241,569,846 | C/T | — | benign |
| rs149473120 | 2:241,569,868 | C/T | — | uncertain significance |
| rs61734452 | 2:241,569,874 | A/G | — | likely benign |
| rs781138951 | 2:241,569,896 | C/T | — | uncertain significance |
| rs768360850 | 2:241,569,924 | C/T | — | likely benign |
| rs146267919 | 2:241,569,925 | G/A | — | uncertain significance |
| rs548051621 | 2:241,569,953 | T/C | — | uncertain significance |
| rs770344320 | 2:241,570,018 | C/T | — | uncertain significance |
| rs147700491 | 2:241,570,035 | C/T | — | benign |
| rs76041925 | 2:241,570,047 | C/T | — | likely benign |
| rs199886367 | 2:241,570,067 | T/C | — | uncertain significance |
| rs373558269 | 2:241,570,072 | G/T | — | uncertain significance |
| rs377190882 | 2:241,570,087 | C/A | — | uncertain significance |
| rs370613558 | 2:241,570,088 | G/T | — | uncertain significance |
| rs145963376 | 2:241,570,093 | G/A | — | uncertain significance |
| rs138617727 | 2:241,570,107 | C/T | — | benign |
| rs756768919 | 2:241,570,135 | C/T | — | uncertain significance |
| rs554457295 | 2:241,570,136 | G/A | — | uncertain significance |
| rs140467268 | 2:241,570,227 | G/A | — | likely benign |
| rs3749172 | 2:241,570,249 | A/C | missense variant | — |
| rs747252797 | 2:241,570,250 | G/A | — | uncertain significance |
| rs2043439501 | 2:241,570,286 | T/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.