rs4676410

This variant is located in the GPR35 gene.

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GWAS Catalog Trait Associations (6)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

platelet volume

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele A
OR 0.02
p 2.0e-13
N 394,642
Large GWAS
European

eosinophil count

Chen MH et al. “Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.” Cell 182(5):1198-1213.e14 (2020)
Allele A
OR 0.02
p 2.0e-10
N 474,237
Large GWAS
European

ankylosing spondylitis

Cortes A et al. “Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci.” Nature Genetics 45(7):730-8 (2013)
Allele T
OR 1.13
p 1.0e-8
N 25,764
Large GWAS
multi-ancestry

Crohn's disease

Khrom M et al. “Sex-Dimorphic Analyses Identify Novel and Sex-Specific Genetic Associations in Inflammatory Bowel Disease.” Inflammatory Bowel Diseases 29(10):1622-1632 (2023)
Allele A
OR 1.13
p 1.0e-8
N 33,105
Large GWAS
European

sex interaction measurement, Crohn's disease

Khrom M et al. “Sex-Dimorphic Analyses Identify Novel and Sex-Specific Genetic Associations in Inflammatory Bowel Disease.” Inflammatory Bowel Diseases 29(10):1622-1632 (2023)
Allele A
OR —
p 4.0e-8
N 58,538
Large GWAS
European
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Research that mentions this SNP (2)

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Associations Between Genetic Variants in the IRGM Gene and Inflammatory Bowel Diseases in the Korean Population
AssociationN=400Chang Mo Moon et al.(2013)· Inflammatory Bowel Diseases

This PhD thesis by Paul Henderson comprises multiple studies on paediatric inflammatory bowel disease (PIBD) in Scotland, including epidemiological studies documenting a 76% rise in IBD incidence, genetic association studies identifying ICOSLG SNP rs8126734-A as overtransmitted in IBD/CD (p=0.0467, OR 1.85 for CD; p=0.0084), CRP gene variants rs1130864-A and rs1417938-A associated with PIBD susceptibility (OR 1.56-1.89 for CD), and functional characterization of NOD2 and autophagy pathways in Crohn's disease pathogenesis.

Traits studied:Colonic IBD unclassifiedCrohn's diseaseInflammatory bowel diseaseUlcerative colitis
PubMedDOIMetascience Observatory
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Phenotype–Genotype Profiles in Crohnʼs Disease Predicted by Genetic Markers in Autophagy-Related Genes (GOIA Study II)
AssociationN=448Cecília Durães et al.(2013)· Inflammatory Bowel Diseases

This PhD thesis encompasses multiple studies on pediatric inflammatory bowel disease (IBD): epidemiological analysis shows rising incidence in Scotland (4.45 to 7.82 per 100,000 per year); transmission disequilibrium testing identified rs8126734-A as overtransmitted in IBD and CD (OR 1.48, p=0.047; OR 1.85 for CD, p=0.008); genome-wide association meta-analysis confirmed strong signals in ICOSLG 3'UTR for CD susceptibility; CRP gene variants (rs1417938, rs1130864) showed significant overtransmission (p=0.006, p=0.015); and faecal calprotectin demonstrated superior diagnostic accuracy for PIBD detection (sensitivity 0.93, specificity 0.74).

Traits studied:Crohn's diseaseInflammatory bowel diseasePediatric inflammatory bowel diseaseUlcerative colitis
PubMedDOIMetascience Observatory

About GPR35

Enables C-X-C chemokine receptor activity. Involved in chemokine-mediated signaling pathway; negative regulation of voltage-gated calcium channel activity; and positive regulation of cytosolic calcium ion concentration. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

View all GPR35 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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