rs3760775
This is a upstream gene variant variant in the FUT6 gene.
▶GWAS Catalog Trait Associations (6)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (6)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
blood protein amount
Gudjonsson A et al. “A genome-wide association study of serum proteins reveals shared loci with common diseases.” Nature Communications 13(1):480 (2022)
Allele T
OR 1.01
p 4.0e-171
N 5,368
Large GWAS
European
alpha-(1,3)-fucosyltransferase 5 measurement
Allele T
OR —
β 0.800
p 2.0e-53
N 3,301
Large GWAS
European
vitamin B12 measurement
Nongmaithem SS et al. “GWAS identifies population-specific new regulatory variants in FUT6 associated with plasma B12 concentrations in Indians.” Human Molecular Genetics 26(13):2551-2564 (2017)
Allele A
OR 0.25
p 1.0e-23
N 1,001
Large GWAS
South Asian
total cholesterol measurement
Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)
Allele T
OR 0.02
p 2.0e-9
N 153,950
Large GWAS
East Asian
low density lipoprotein cholesterol measurement
Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)
Allele T
OR 0.02
p 3.0e-9
N 153,950
Large GWAS
East Asian
cancer biomarker measurement
He M et al. “A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.” Gut 63(1):143-51 (2014)
Allele T
OR 0.07
p 1.0e-35
N 3,451
Large GWAS
East Asian
About FUT6
The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X, an E-selectin ligand. Mutations in this gene are a cause of fucosyltransferase-6 deficiency. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
View all FUT6 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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