rs3791033
This is a intron variant variant in the KDM4A gene.
▶GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
self reported educational attainment
Lee JJ et al. “Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.” Nature Genetics 50(8):1112-1121 (2018)
Allele T
OR 0.01
p 2.0e-17
N 1,131,881
Large GWAS
European
physical activity measurement
Wang Z et al. “Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention.” Nature Genetics 54(9):1332-1344 (2022)
Allele C
OR 0.03
p 4.0e-16
N 526,725
Large GWAS
European
opioid use disorder
Sanchez-Roige S et al. “Genome-wide association study of problematic opioid prescription use in 132,113 23andMe research participants of European ancestry.” Molecular Psychiatry 26(11):6209-6217 (2021)
Allele T
OR 5.49
p 4.0e-8
N 132,113
Major Consortium StudyLarge GWAS
European
glucose measurement
Lagou V et al. “GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification.” Nature Genetics 55(9):1448-1461 (2023)
Allele T
OR 0.00
p 4.0e-8
N 458,862
Large GWAS
European
substance-related disorder
Lai D et al. “Genome-wide meta-analyses of cross substance use disorders in diverse populations.” Molecular Psychiatry 31(3):1619-1633 (2026)
Allele T
OR 7.09
p 1.0e-12
N 1,699,295
Large GWAS
multi-ancestry
About KDM4A
This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. [provided by RefSeq, Apr 2009]
View all KDM4A variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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