rs3793577

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GWAS Catalog Trait Associations (6)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

major depressive disorder

Howard DM et al. “Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.” Nature Neuroscience 22(3):343-352 (2019)
Allele G
OR 1.02
p 6.0e-22
N 807,553
Meta-analysisLarge GWAS
European
Meng X et al. “Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference.” Nature Genetics 56(2):222-233 (2024)
Allele G
OR 0.02
p 3.0e-11
N 1,820,689
Large GWAS
multi-ancestry
Als TD et al. “Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses.” Nature Medicine 29(7):1832-1844 (2023)
Allele G
OR 0.02
p 4.0e-15
N 1,349,887
Large GWAS
European
Giannakopoulou O et al. “The Genetic Architecture of Depression in Individuals of East Asian Ancestry: A Genome-Wide Association Study.” Jama Psychiatry 78(11):1258-1269 (2021)
Allele G
OR 0.01
p 7.0e-9
N 694,747
Large GWAS
multi-ancestry
Nagel M et al. “Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.” Nature Genetics 50(7):920-927 (2018)
Allele G
OR 6.99
p 3.0e-12
N 688,809
Meta-analysisLarge GWAS
European

depressive symptom measurement

Baselmans BML et al. “Multivariate genome-wide analyses of the well-being spectrum.” Nature Genetics 51(3):445-451 (2019)
Allele G
OR 0.01
p 7.0e-13
N 1,067,913
Large GWAS
European

neuroticism measurement

Baselmans BML et al. “Multivariate genome-wide analyses of the well-being spectrum.” Nature Genetics 51(3):445-451 (2019)
Allele G
OR 0.01
p 7.0e-13
N 523,783
Large GWAS
European

irritable bowel syndrome

Alemany S et al. “Genome-wide multi-trait analysis of irritable bowel syndrome and related mental conditions identifies 38 new independent variants.” Journal of Translational Medicine 21(1):272 (2023)
Allele A
OR 0.01
p 3.0e-10
N 887,490
Large GWAS
European

social interaction measurement

Bralten J et al. “Genetic underpinnings of sociability in the general population.” Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology 46(9):1627-1634 (2021)
Allele A
OR —
β 0.013
p 5.0e-10
N 342,461
Large GWAS
European

wellbeing measurement

Baselmans BML et al. “Multivariate genome-wide analyses of the well-being spectrum.” Nature Genetics 51(3):445-451 (2019)
Allele G
OR 0.01
p 3.0e-12
N 80,852
Large GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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