rs3809297
This is a intron variant variant in the CUX2 gene.
▶GWAS Catalog Trait Associations (9)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (9)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
high density lipoprotein cholesterol measurement
Lee SB et al. “Dyslipidaemia-Genotype Interactions with Nutrient Intake and Cerebro-Cardiovascular Disease.” Biomedicines 10(7) (2022)
Allele T
OR 1.08
p 1.0e-26
N 58,701
Large GWAS
East Asian
neutrophil count
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele T
OR 0.05
p 4.0e-19
N 82,810
Large GWAS
East Asian
Graves disease
White SL et al. “Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases.” Nature Genetics 58(2):307-316 (2026)
Allele T
OR 0.27
p 7.0e-18
N 2,460,657
Large GWAS
multi-ancestry
cardiac arrhythmia
Ishigaki K et al. “Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases.” Nature Genetics 52(7):669-679 (2020)
Allele T
OR 0.89
p 4.0e-15
N 212,453
Large GWAS
East Asian
glomerular filtration rate
Lee DJ et al. “Genome-wide association study and fine-mapping on Korean biobank to discover renal trait-associated variants.” Kidney Research and Clinical Practice 43(3):299-312 (2024)
Allele T
OR 0.67
p 2.0e-13
N 58,406
Large GWAS
East Asian
carbohydrate intake measurement
Nakamura Y et al. “A genome-wide association study on adherence to low-carbohydrate diets in Japanese.” European Journal of Clinical Nutrition 76(8):1103-1110 (2022)
Allele T
OR 1.22
p 7.0e-12
N 6,332
Large GWAS
East Asian
blood urea nitrogen amount
Lee DJ et al. “Genome-wide association study and fine-mapping on Korean biobank to discover renal trait-associated variants.” Kidney Research and Clinical Practice 43(3):299-312 (2024)
Allele T
OR 0.01
p 2.0e-11
N 58,406
Large GWAS
East Asian
pulse pressure measurement
Takeuchi F et al. “Interethnic analyses of blood pressure loci in populations of East Asian and European descent.” Nature Communications 9(1):5052 (2018)
Allele T
OR 0.42
p 2.0e-11
N 130,777
Large GWAS
multi-ancestry
BMI-adjusted waist-hip ratio, forced expiratory volume
Zhu Z et al. “A large-scale genome-wide association analysis of lung function in the Chinese population identifies novel loci and highlights shared genetic aetiology with obesity.” The European Respiratory Journal 58(4) (2021)
Allele G
OR —
p 3.0e-11
N 100,285
Large GWAS
multi-ancestry
About CUX2
This gene encodes a protein which contains three CUT domains and a homeodomain; both domains are DNA-binding motifs. A similar gene, whose gene product possesses different DNA-binding activities, is located on chromosome on chromosome 7. Two pseudogenes of this gene have been identified on chromosomes 10 and 4. [provided by RefSeq, Jan 2013]
View all CUX2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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