rs3842753
This variant is located in the INS;INS-IGF2;TH gene.
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
type 1 diabetes mellitus
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele G
OR 0.31
p 8.0e-44
N 590,946
Large GWAS
multi-ancestry
glucose measurement
Lagou V et al. “GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification.” Nature Genetics 55(9):1448-1461 (2023)
Allele T
OR 0.00
p 1.0e-21
N 475,416
Large GWAS
multi-ancestry
Chen J et al. “The trans-ancestral genomic architecture of glycemic traits.” Nature Genetics 53(6):840-860 (2021)
Allele T
OR —
β 0.013
p 3.0e-9
N 200,622
Large GWAS
European
HbA1c measurement
Chen J et al. “The trans-ancestral genomic architecture of glycemic traits.” Nature Genetics 53(6):840-860 (2021)
Allele T
OR 0.01
p 4.0e-8
N 146,806
Large GWAS
European
▶ClinVar annotation
Conflicting Classifications
5 submitters2 publicationsMaturity-onset diabetes of the young; Autosomal recessive DOPA responsive dystonia; Transient Neonatal Diabetes, Dominant/Recessive; Maturity-onset diabetes of the young type 10; Type 1 diabetes mellitus 2; Hyperproinsulinemia; Diabetes mellitus, permanent neonatal 4; not provided; Diabetes mellitus type 1
View on ClinVar →This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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