rs424232

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

complement C4 measurement

Borbye-Lorenzen N et al. “The correlates of neonatal complement component 3 and 4 protein concentrations with a focus on psychiatric and autoimmune disorders.” Cell Genomics 3(12):100457 (2023)
Allele T
OR 0.26
p 1.0e-300
N 68,768
Large GWAS
European
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Research that mentions this SNP (1)

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Search for schizophrenia susceptibility variants at the HLA-DRB1 locus among a British population
AssociationN=487Lorna Halley et al.(2013)· Immunogenetics

A candidate gene association study of HLA-DRB1 tagging SNPs in schizophrenia among 332 British cases (219 male, 113 female; mean age 32-36 years) and 155 controls (mean age 40-42 years) recruited through family-based (132 trios, 92 duos) and case-control designs. The DRB1*1303 allele showed marginal protective association (OR=0.42, 95% CI 0.27-0.66, χ²=4.138, P=0.042), and rs424232 showed significant protective association with schizophrenia (OR=0.69, 95% CI 0.54-0.88, χ²=9.404, P=0.002). The authors failed to confirm association of candidate DRB1 risk alleles but noted the association signal may extend beyond the HLA locus toward the NOTCH4 gene.

Traits studied:Schizophrenia
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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