rs4380187

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

schizophrenia

Yao X et al. “Integrative analysis of genome-wide association studies identifies novel loci associated with neuropsychiatric disorders.” Translational Psychiatry 11(1):69 (2021)
Allele A
OR 0.07
p 8.0e-12
N 77,096
Large GWAS
European

bipolar disorder

Yao X et al. “Integrative analysis of genome-wide association studies identifies novel loci associated with neuropsychiatric disorders.” Translational Psychiatry 11(1):69 (2021)
Allele A
OR 0.07
p 1.0e-10
N 51,710
Large GWAS
European
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Research that mentions this SNP (1)

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Evaluation of the relationship between VRK2, rs4380187 polymorphisms, and genetic susceptibility to schizophrenia in the Chinese Han population
AssociationN=986Xianglai Liu et al.(2021)· The Journal of Gene Medicine

A case-control study in 493 Chinese Han schizophrenia patients and 493 controls found that the C allele of rs4380187 (near ZNF804A) was significantly associated with decreased schizophrenia risk (OR=0.79, 95% CI: 0.66-0.94, p=0.008). The AA genotype showed significantly lower frequency in cases (OR=0.62, p=0.009), and associations were stronger in males (OR=0.64-0.68, p=0.002-0.003) and individuals aged ≥36 years.

Traits studied:schizophrenia
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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