rs45527431
This is a 3 prime utr variant variant in the ABT1 gene.
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
cognitive function measurement, self reported educational attainment
Demange PA et al. “Investigating the genetic architecture of noncognitive skills using GWAS-by-subtraction.” Nature Genetics 53(1):35-44 (2021)
Allele A
OR 0.11
p 2.0e-18
N 257,700
Large GWAS
European
major depressive disorder
Howard DM et al. “Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways.” Nature Communications 9(1):1470 (2018)
Allele G
OR 0.01
p 2.0e-9
N 322,580
Major Consortium StudyLarge GWAS
European
handedness
Cuellar-Partida G et al. “Genome-wide association study identifies 48 common genetic variants associated with handedness.” Nature Human Behaviour 5(1):59-70 (2021)
Allele A
OR 1.04
p 5.0e-9
N 1,766,671
Large GWAS
European
About ABT1
Basal transcription of genes by RNA polymerase II requires the interaction of TATA-binding protein (TBP) with the core region of class II promoters. Studies in mouse suggest that the protein encoded by this gene likely activates basal transcription from class II promoters by interaction with TBP and the class II promoter DNA. [provided by RefSeq, Jul 2008]
View all ABT1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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