rs472140

This is a regulatory region variant variant.

▶

GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

cannabis dependence

Levey DF et al. “Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications.” Nature Genetics 55(12):2094-2103 (2023)

Allele T

OR 0.02

p 1.0e-10

N 200,762

Large GWAS

European

alcohol use disorder measurement

Kember RL et al. “Genetic Underpinnings of the Transition From Alcohol Consumption to Alcohol Use Disorder: Shared and Unique Genetic Architectures in a Cross-Ancestry Sample.” The American Journal of Psychiatry 180(8):584-593 (2023)

Allele C

OR 0.96

p 2.0e-10

N 296,989

Large GWAS

European

alcohol consumption quality

Kember RL et al. “Genetic Underpinnings of the Transition From Alcohol Consumption to Alcohol Use Disorder: Shared and Unique Genetic Architectures in a Cross-Ancestry Sample.” The American Journal of Psychiatry 180(8):584-593 (2023)

Allele C

OR 0.04

p 4.0e-8

N 296,989

Large GWAS

European

substance-related disorder

Lai D et al. “Genome-wide meta-analyses of cross substance use disorders in diverse populations.” Molecular Psychiatry 31(3):1619-1633 (2026)

Allele T

OR 10.87

p 2.0e-27

N 1,517,369

Large GWAS

multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Sign in to join the discussion.

Loading comments…