rs4764133
▶GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
osteoarthritis, hand
den Hollander W et al. “Genome-wide association and functional studies identify a role for matrix Gla protein in osteoarthritis of the hand.” Annals of the Rheumatic Diseases 76(12):2046-2053 (2017)
Allele T
OR 0.83
p 2.0e-15
N 8,743
Large GWAS
European
Boer CG et al. “Genome-wide association of phenotypes based on clustering patterns of hand osteoarthritis identify WNT9A as novel osteoarthritis gene.” Annals of the Rheumatic Diseases 80(3):367-375 (2021)
Allele T
OR 0.81
p 3.0e-12
N 4,829
Large GWAS
European
osteoarthritis, hip, osteoarthritis, knee
Hatzikotoulas K et al. “Translational genomics of osteoarthritis in 1,962,069 individuals.” Nature 641(8065):1217-1224 (2025)
Allele T
OR 0.97
p 8.0e-13
N 1,294,321
Large GWAS
multi-ancestry
osteoarthritis, knee
Hatzikotoulas K et al. “Translational genomics of osteoarthritis in 1,962,069 individuals.” Nature 641(8065):1217-1224 (2025)
Allele T
OR 0.97
p 2.0e-11
N 1,316,500
Large GWAS
multi-ancestry
grip strength measurement
Jones G et al. “Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women.” Nature Communications 12(1):654 (2021)
Allele T
OR —
β 0.054
p 4.0e-9
N 135,468
Meta-analysisLarge GWAS
European
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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