rs4791331

This is a intron variant variant in the NTN1 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

neuroticism measurement

Nagel M et al. “Genome-wide association study of the sensitivity to environmental stress and adversity neuroticism cluster.” Acta Psychiatrica Scandinavica 141(5):476-478 (2020)

Allele T

OR —

β 0.014

p 3.0e-9

N 351,827

Large GWAS

European

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ClinVar annotation

Uncertain Significance★☆☆☆

2 submitters

Nonsyndromic cleft lip with or without cleft palate

View on ClinVar →

About NTN1

Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development. [provided by RefSeq, Jul 2008]

View all NTN1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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