rs4791774

This variant is located in the NTN1 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Cleft palate, cleft lip

Sun Y et al. “Genome-wide association study identifies a new susceptibility locus for cleft lip with or without a cleft palate.” Nature Communications 6:6414 (2015)

Allele G

OR 1.56

p 5.0e-19

N 2,106

Large GWAS

East Asian

feeling emotionally hurt measurement

Nagel M et al. “Item-level analyses reveal genetic heterogeneity in neuroticism.” Nature Communications 9(1):905 (2018)

Allele A

OR 5.49

p 4.0e-8

N 372,047

Large GWAS

European

About NTN1

Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development. [provided by RefSeq, Jul 2008]

View all NTN1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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