rs479844

This is a upstream gene variant variant.

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GWAS Catalog Trait Associations (11)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

asthma

Han Y et al. “Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma.” Nature Communications 11(1):1776 (2020)
Allele G
OR —
p 2.0e-22
N 536,345
Large GWAS
multi-ancestry
Valette K et al. “Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank.” Communications Biology 4(1):700 (2021)
Allele G
OR 0.04
p 8.0e-10
N 408,422
Major Consortium StudyLarge GWAS
European
Ferreira MAR et al. “Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.” American Journal of Human Genetics 104(4):665-684 (2019)
Allele G
OR 1.05
p 3.0e-14
N 341,215
Large GWAS
European
Johansson Å et al. “Genome-wide association analysis of 350 000 Caucasians from the UK Biobank identifies novel loci for asthma, hay fever and eczema.” Human Molecular Genetics 28(23):4022-4041 (2019)
Allele G
OR —
p 4.0e-11
N 281,699
Major Consortium StudyLarge GWAS
European

atopic eczema

Chen Y et al. “Genome-Wide Integration of Genetic and Genomic Studies of Atopic Dermatitis: Insights into Genetic Architecture and Pathogenesis.” The Journal of Investigative Dermatology 142(11):2958-2967.e8 (2022)
Allele G
OR 0.08
p 4.0e-20
N 837,496
Large GWAS
multi-ancestry
Sliz E et al. “Uniting biobank resources reveals novel genetic pathways modulating susceptibility for atopic dermatitis.” The Journal of Allergy and Clinical Immunology 149(3):1105-1112.e9 (2022)
Allele G
OR 0.93
p 2.0e-12
N 796,661
Large GWAS
European
Paternoster L et al. “Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis.” Nature Genetics 44(2):187-92 (2011)
Allele G
OR 1.14
p 1.0e-13
N 26,171
Meta-analysisLarge GWAS
European

total lipids in large LDL

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele G
OR 0.02
p 1.0e-18
N 450,015
Large GWAS
multi-ancestry

asthma, Eczematoid dermatitis, allergic rhinitis

Johansson Å et al. “Genome-wide association analysis of 350 000 Caucasians from the UK Biobank identifies novel loci for asthma, hay fever and eczema.” Human Molecular Genetics 28(23):4022-4041 (2019)
Allele G
OR 1.05
p 3.0e-17
N 346,545
Major Consortium StudyLarge GWAS
European

Eczematoid dermatitis, allergic rhinitis

Johansson Å et al. “Genome-wide association analysis of 350 000 Caucasians from the UK Biobank identifies novel loci for asthma, hay fever and eczema.” Human Molecular Genetics 28(23):4022-4041 (2019)
Allele G
OR 1.05
p 6.0e-17
N 323,807
Major Consortium StudyLarge GWAS
European

allergic disease

Ferreira MA et al. “Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology.” Nature Genetics 49(12):1752-1757 (2017)
Allele G
OR 1.04
p 2.0e-13
N 360,838
Large GWAS
European

serum IgG glycosylation measurement

Shadrina AS et al. “Multivariate genome-wide analysis of immunoglobulin G N-glycosylation identifies new loci pleiotropic with immune function.” Human Molecular Genetics 30(13):1259-1270 (2021)
Allele A
OR 0.02
p 2.0e-13
N 8,090
Large GWAS
European

childhood onset asthma

Pividori M et al. “Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.” The Lancet. Respiratory Medicine 7(6):509-522 (2019)
Allele G
OR 1.11
p 1.0e-11
N 327,670
Large GWAS
European

atopic eczema, childhood onset asthma, atopic march

Marenholz I et al. “Meta-analysis identifies seven susceptibility loci involved in the atopic march.” Nature Communications 6:8804 (2015)
Allele G
OR 1.25
p 4.0e-10
N 11,181
Meta-analysisLarge GWAS
European

systemic lupus erythematosus

Khunsriraksakul C et al. “Multi-ancestry and multi-trait genome-wide association meta-analyses inform clinical risk prediction for systemic lupus erythematosus.” Nature Communications 14(1):668 (2023)
Allele A
OR 0.06
p 1.0e-8
N 718,496
Large GWAS
multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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