rs486349

This variant is located in the TTC39B gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

high density lipoprotein cholesterol measurement

Hoffmann TJ et al. “A large electronic-health-record-based genome-wide study of serum lipids.” Nature Genetics 50(3):401-413 (2018)

Allele G

OR —

β 0.044

p 7.0e-15

N 94,674

Large GWAS

multi-ancestry

About TTC39B

Predicted to be involved in several processes, including cholesterol homeostasis; negative regulation of cholesterol storage; and regulation of cholesterol efflux. [provided by Alliance of Genome Resources, Jul 2025]

View all TTC39B variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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