rs5016282

This variant is located in the GRM5 gene.

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

high density lipoprotein cholesterol measurement

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)
Allele G
OR 0.04
p 3.0e-27
N 325,634
Major Consortium StudyLarge GWAS
multi-ancestry

IGF-1 measurement

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)
Allele G
OR 0.03
p 2.0e-21
N 353,824
Major Consortium StudyLarge GWAS
multi-ancestry

apolipoprotein A 1 measurement

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)
Allele G
OR 0.03
p 4.0e-14
N 323,833
Major Consortium StudyLarge GWAS
multi-ancestry

C-reactive protein measurement

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)
Allele G
OR 0.02
p 2.0e-9
N 355,127
Major Consortium StudyLarge GWAS
multi-ancestry
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Research that mentions this SNP (1)

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Genome‐wide association study in German patients with attention deficit/hyperactivity disorder
AssociationN=1,795Anke Hinney et al.(2011)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

A genome-wide association study in 495 German ADHD patients and 1,300 population-based controls identified 30 independent SNPs with p-values below 7.57×10^-5 for replication testing. The best SNP (rs2556378 in BCL11A, p=8.38×10^-7, OR=1.61) and second-best SNP (rs5016282 in GRM5, p=1.78×10^-6, OR=1.85) showed directionally consistent effects in replication families (n=320) and meta-analysis, but no genome-wide significant results (p<5×10^-8) were achieved despite high ADHD heritability.

Traits studied:Attention Deficit/Hyperactivity Disorder (ADHD)
PubMedDOIMetascience Observatory

About GRM5

This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

View all GRM5 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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