rs56393506
▶GWAS Catalog Trait Associations (24)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (24)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
lipoprotein A measurement
Mack S et al. “A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms.” Journal of Lipid Research 58(9):1834-1844 (2017)
Allele T
OR 13.60
p 8.0e-285
N 13,781
Meta-analysisLarge GWAS
European
phospholipids:total lipids ratio
Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele T
OR 0.08
p 4.0e-182
N 450,015
Large GWAS
multi-ancestry
Davyson E et al. “Metabolomic Investigation of Major Depressive Disorder Identifies a Potentially Causal Association With Polyunsaturated Fatty Acids.” Biological Psychiatry 94(8):630-639 (2023)
Allele T
OR 0.12
p 8.0e-72
N 85,701
Large GWAS
European
free cholesterol to total lipids in large VLDL percentage
Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele T
OR 0.07
p 6.0e-148
N 450,015
Large GWAS
multi-ancestry
lipoprotein A measurement, apolipoprotein A 1 measurement
Mack S et al. “A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms.” Journal of Lipid Research 58(9):1834-1844 (2017)
Allele T
OR 7.07
p 3.0e-105
N 13,781
Meta-analysisLarge GWAS
European
low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio
Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)
Allele C
OR 0.12
p 9.0e-100
N 115,082
Large GWAS
European
phospholipids:total lipids ratio, blood VLDL cholesterol amount, chylomicron amount
Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)
Allele C
OR 0.11
p 7.0e-92
N 111,638
Large GWAS
European
low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio
Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)
Allele C
OR 0.10
p 1.0e-78
N 115,082
Large GWAS
European
cholesteryl esters to total lipids in medium LDL percentage
Davyson E et al. “Metabolomic Investigation of Major Depressive Disorder Identifies a Potentially Causal Association With Polyunsaturated Fatty Acids.” Biological Psychiatry 94(8):630-639 (2023)
Allele T
OR 0.11
p 5.0e-73
N 88,329
Large GWAS
European
LDL particle size
Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)
Allele C
OR 0.09
p 2.0e-65
N 115,082
Large GWAS
European
Agouti-related protein measurement
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele T
OR 0.09
p 7.0e-35
N 47,745
Large GWAS
European
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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