rs569550

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GWAS Catalog Trait Associations (15)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

systolic blood pressure

Keaton JM et al. “Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.” Nature Genetics 56(5):778-791 (2024)

Allele G

OR 0.49

p 2.0e-83

N 1,028,980

Large GWAS

multi-ancestry

Koskeridis F et al. “Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits.” Nature Communications 15(1):9827 (2024)

Allele G

OR 0.03

p 1.0e-68

N 1,212,859

Large GWAS

European

Giri A et al. “Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.” Nature Genetics 51(1):51-62 (2019)

Allele G

OR 0.40

p 1.0e-30

N 459,777

Large GWAS

multi-ancestry

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.03

p 6.0e-43

N 425,750

Major Consortium StudyLarge GWAS

European

Shi G et al. “Genome-wide variance quantitative trait locus analysis suggests small interaction effects in blood pressure traits.” Scientific Reports 12(1):12649 (2022)

Allele G

OR 0.63

p 3.0e-49

N 396,077

Large GWAS

European

Takeuchi F et al. “Interethnic analyses of blood pressure loci in populations of East Asian and European descent.” Nature Communications 9(1):5052 (2018)

Allele G

OR 0.59

p 3.0e-10

N 130,777

Large GWAS

multi-ancestry

Pozarickij A et al. “Causal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adults.” Nature Communications 15(1):6265 (2024)

Allele G

OR 0.83

p 3.0e-14

N 100,453

Large GWAS

East Asian

diastolic blood pressure

Allele G

OR 0.24

p 2.0e-52

N 1,028,980

Large GWAS

multi-ancestry

Koskeridis F et al. “Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits.” Nature Communications 15(1):9827 (2024)

Allele G

OR 0.03

p 7.0e-48

N 1,212,859

Large GWAS

European

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.03

p 3.0e-23

N 609,354

Major Consortium StudyLarge GWAS

multi-ancestry

Plotnikov D et al. “High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study.” Investigative Ophthalmology & Visual Science 63(6):29 (2022)

Allele G

OR 0.25

p 2.0e-29

N 526,001

Large GWAS

European

Shi G et al. “Genome-wide variance quantitative trait locus analysis suggests small interaction effects in blood pressure traits.” Scientific Reports 12(1):12649 (2022)

Allele G

OR 0.28

p 1.0e-30

N 396,079

Large GWAS

European

Takeuchi F et al. “Interethnic analyses of blood pressure loci in populations of East Asian and European descent.” Nature Communications 9(1):5052 (2018)

Allele G

OR 0.35

p 5.0e-9

N 130,777

Large GWAS

multi-ancestry

Allele G

OR 0.45

p 2.0e-14

N 100,453

Large GWAS

East Asian

pulse pressure measurement

Allele G

OR 0.27

p 2.0e-50

N 1,028,980

Large GWAS

multi-ancestry

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele G

OR 0.02

p 1.0e-24

N 506,308

Large GWAS

multi-ancestry

Allele G

OR 0.39

p 4.0e-8

N 100,453

Large GWAS

East Asian

hypertension

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele G

OR 0.06

p 3.0e-32

N 394,626

Large GWAS

European

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.05

p 3.0e-28

N 428,138

Major Consortium StudyLarge GWAS

European

Takeuchi F et al. “Interethnic analyses of blood pressure loci in populations of East Asian and European descent.” Nature Communications 9(1):5052 (2018)

Allele G

OR 0.10

p 1.0e-8

N 50,792

Large GWAS

multi-ancestry

Diuretic use measurement

Wu Y et al. “Genome-wide association study of medication-use and associated disease in the UK Biobank.” Nature Communications 10(1):1891 (2019)

Allele G

OR 0.09

p 2.0e-31

N 229,086

Major Consortium StudyLarge GWAS

European

Calcium channel blocker use measurement

Wu Y et al. “Genome-wide association study of medication-use and associated disease in the UK Biobank.” Nature Communications 10(1):1891 (2019)

Allele G

OR 0.10

p 9.0e-31

N 204,378

Major Consortium StudyLarge GWAS

European

essential hypertension

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele T

OR 0.06

p 5.0e-30

N 427,704

Major Consortium StudyLarge GWAS

European

potassium deficiency disease

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele T

OR 0.08

p 6.0e-18

N 595,013

Major Consortium StudyLarge GWAS

multi-ancestry

Beta blocking agent use measurement

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele G

OR 0.06

p 1.0e-16

N 402,750

Large GWAS

multi-ancestry

renin measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele G

OR 0.04

p 4.0e-14

N 47,745

Large GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

rs569550

GWAS Catalog Trait Associations (15)

systolic blood pressure

diastolic blood pressure

pulse pressure measurement

hypertension

Diuretic use measurement

Calcium channel blocker use measurement

essential hypertension

potassium deficiency disease

Beta blocking agent use measurement

renin measurement

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