rs61754230

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GWAS Catalog Trait Associations (9)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

body mass index

Huang J et al. “Genomics and phenomics of body mass index reveals a complex disease network.” Nature Communications 13(1):7973 (2022)

Allele C

OR 0.04

p 9.0e-19

N 1,122,049

Large GWAS

European

Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)

Allele C

OR 0.06

p 1.0e-10

N 928,679

Large GWAS

multi-ancestry

Pulit SL et al. “Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.” Human Molecular Genetics 28(1):166-174 (2019)

Allele C

OR 0.05

p 1.0e-10

N 806,834

Meta-analysisLarge GWAS

European

Koskeridis F et al. “Pleiotropic genetic architecture and novel loci for C-reactive protein levels.” Nature Communications 13(1):6939 (2022)

Allele C

OR 0.05

p 4.0e-10

N 694,649

Large GWAS

European

Turcot V et al. “Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.” Nature Genetics 50(1):26-41 (2018)

Allele C

OR 0.04

p 1.0e-9

N 526,508

Large GWAS

multi-ancestry

Hawkes G et al. “Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretion, after accounting for BMI in adulthood.” Diabetologia 66(8):1472-1480 (2023)

Allele C

OR 0.04

p 7.0e-10

N 441,761

Large GWAS

European

aspartate aminotransferase measurement

Allele T

OR 0.07

p 4.0e-17

N 928,679

Large GWAS

multi-ancestry

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele T

OR 0.05

p 1.0e-10

N 493,058

Large GWAS

multi-ancestry

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele T

OR 0.05

p 3.0e-14

N 394,642

Large GWAS

European

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)

Allele T

OR 0.06

p 4.0e-11

N 354,541

Major Consortium StudyLarge GWAS

multi-ancestry

low density lipoprotein cholesterol measurement

Graham SE et al. “The power of genetic diversity in genome-wide association studies of lipids.” Nature 600(7890):675-679 (2021)

Allele T

OR 0.05

p 1.0e-13

N 1,320,016

Large GWAS

European

Allele T

OR 0.06

p 1.0e-10

N 928,679

Large GWAS

multi-ancestry

Richardson TG et al. “Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis.” Plos Medicine 17(3):e1003062 (2020)

Allele T

OR 0.04

p 1.0e-8

N 440,546

Large GWAS

European

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)

Allele T

OR 0.06

p 2.0e-13

N 355,197

Major Consortium StudyLarge GWAS

multi-ancestry

Liu DJ et al. “Exome-wide association study of plasma lipids in >300,000 individuals.” Nature Genetics 49(12):1758-1766 (2017)

Allele T

OR 0.05

p 4.0e-12

N 297,824

Large GWAS

multi-ancestry

non-high density lipoprotein cholesterol measurement

Graham SE et al. “The power of genetic diversity in genome-wide association studies of lipids.” Nature 600(7890):675-679 (2021)

Allele T

OR 0.06

p 7.0e-13

N 1,320,016

Large GWAS

European

apolipoprotein B measurement

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)

Allele T

OR 0.06

p 1.0e-12

N 354,097

Major Consortium StudyLarge GWAS

multi-ancestry

Allele T

OR 0.04

p 1.0e-8

N 439,214

Large GWAS

European

total cholesterol measurement

Graham SE et al. “The power of genetic diversity in genome-wide association studies of lipids.” Nature 600(7890):675-679 (2021)

Allele T

OR 0.05

p 1.0e-12

N 1,320,016

Large GWAS

European

Allele T

OR 0.05

p 3.0e-9

N 928,679

Large GWAS

multi-ancestry

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)

Allele T

OR 0.06

p 2.0e-12

N 355,858

Major Consortium StudyLarge GWAS

multi-ancestry

body weight

Allele T

OR 0.05

p 2.0e-9

N 928,679

Large GWAS

multi-ancestry

body height

Richardson TG et al. “Use of genetic variation to separate the effects of early and later life adiposity on disease risk: mendelian randomisation study.” Bmj (clinical Research Ed.) 369:m1203 (2020)

Allele C

OR 0.03

p 3.0e-8

N 453,169

Large GWAS

European

intelligence

Davies G et al. “Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.” Nature Communications 9(1):2098 (2018)

Allele T

OR 5.46

p 5.0e-8

N 300,486

Large GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

rs61754230

GWAS Catalog Trait Associations (9)

body mass index

aspartate aminotransferase measurement

low density lipoprotein cholesterol measurement

non-high density lipoprotein cholesterol measurement

apolipoprotein B measurement

total cholesterol measurement

body weight

body height

intelligence

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