rs62062288

This is a intron variant variant in the MAPT gene.

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GWAS Catalog Trait Associations (9)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

neuroticism measurement

Nagel M et al. “Item-level analyses reveal genetic heterogeneity in neuroticism.” Nature Communications 9(1):905 (2018)
Allele A
OR 11.77
p 6.0e-32
N 380,506
Large GWAS
European
Wendt FR et al. “Sex-Specific Genetic and Transcriptomic Liability to Neuroticism.” Biological Psychiatry 93(3):243-252 (2023)
Allele A
OR 0.11
p 6.0e-13
N 129,229
Large GWAS
European

neurotic disorder

Cai N et al. “Minimal phenotyping yields genome-wide association signals of low specificity for major depression.” Nature Genetics 52(4):437-447 (2020)
Allele A
OR 0.02
p 7.0e-22
N 274,107
Large GWAS
European

transferrin receptor protein 1 measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele A
OR 0.05
p 1.0e-18
N 47,745
Large GWAS
European

amount of iron in brain

Casanova F et al. “MRI-derived brain iron, grey matter volume, and risk of dementia and Parkinson's disease: Observational and genetic analysis in the UK Biobank cohort.” Neurobiology of Disease 197:106539 (2024)
Allele G
OR 0.06
p 5.0e-15
N 39,533
Major Consortium StudyLarge GWAS
European

alcohol use disorder measurement

Sanchez-Roige S et al. “Genome-Wide Association Study Meta-Analysis of the Alcohol Use Disorders Identification Test (AUDIT) in Two Population-Based Cohorts.” The American Journal of Psychiatry 176(2):107-118 (2019)
Allele A
OR 6.21
p 5.0e-10
N 141,932
Meta-analysisLarge GWAS
European

guilt measurement

Nagel M et al. “Item-level analyses reveal genetic heterogeneity in neuroticism.” Nature Communications 9(1):905 (2018)
Allele A
OR 6.17
p 7.0e-10
N 373,380
Large GWAS
European

alcohol consumption quality

Sanchez-Roige S et al. “Genome-Wide Association Study Meta-Analysis of the Alcohol Use Disorders Identification Test (AUDIT) in Two Population-Based Cohorts.” The American Journal of Psychiatry 176(2):107-118 (2019)
Allele A
OR 0.01
p 2.0e-9
N 121,604
Meta-analysisLarge GWAS
European

worry measurement

Nagel M et al. “Item-level analyses reveal genetic heterogeneity in neuroticism.” Nature Communications 9(1):905 (2018)
Allele A
OR 5.50
p 4.0e-8
N 367,725
Large GWAS
European

About MAPT

This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]

View all MAPT variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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