rs6420484
This variant is located in the TSPAN10 gene.
▶GWAS Catalog Trait Associations (6)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (6)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
eye color
Simcoe M et al. “Genome-wide association study in almost 195,000 individuals identifies 50 previously unidentified genetic loci for eye color.” Science Advances 7(11) (2021)
Allele G
OR 0.16
p 8.0e-90
N 157,485
Large GWAS
multi-ancestry
Strabismus
He W et al. “Large-scale GWAS of strabismus identifies risk loci and provides support for a link with maternal smoking.” Nature Communications 16(1):7890 (2025)
Allele A
OR 0.06
p 2.0e-19
N 975,385
Large GWAS
European
corneal resistance factor
He W et al. “Association of Novel Loci With Keratoconus Susceptibility in a Multitrait Genome-Wide Association Study of the UK Biobank Database and Canadian Longitudinal Study on Aging.” Jama Ophthalmology 140(6):568-576 (2022)
Allele A
OR 0.03
p 7.0e-12
N 123,734
Major Consortium StudyLarge GWAS
European
central corneal thickness
He W et al. “Association of Novel Loci With Keratoconus Susceptibility in a Multitrait Genome-Wide Association Study of the UK Biobank Database and Canadian Longitudinal Study on Aging.” Jama Ophthalmology 140(6):568-576 (2022)
Allele A
OR 1.65
p 6.0e-11
N 17,803
Major Consortium StudyLarge GWAS
European
refractive error, age at onset, Myopia
Tedja MS et al. “Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error.” Nature Genetics 50(6):834-848 (2018)
Allele A
OR 5.94
p 3.0e-9
N 170,420
Meta-analysisLarge GWAS
multi-ancestry
Esotropia
He W et al. “Large-scale GWAS of strabismus identifies risk loci and provides support for a link with maternal smoking.” Nature Communications 16(1):7890 (2025)
Allele A
OR 0.07
p 6.0e-9
N 594,757
Large GWAS
European
▶ClinVar annotation
Benign★★★☆
2 submitters1 publicationAbout TSPAN10
Enables enzyme binding activity. Involved in establishment of protein localization to organelle. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
View all TSPAN10 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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