rs6472419
This is a intron variant variant in the C8orf34 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
Dupuytren Contracture
Riesmeijer SA et al. “A genome-wide association meta-analysis implicates Hedgehog and Notch signaling in Dupuytren's disease.” Nature Communications 15(1):199 (2024)
Allele A
OR 0.12
p 1.0e-10
N 58,343
Meta-analysisLarge GWAS
European
About C8orf34
This gene encodes a protein that is related to the cyclic AMP dependent protein kinase regulators. Naturally occurring mutations in this gene are associated with an increased risk for severe toxicities, such as diarrhea and neutropenia, in patients undergoing chemotherapeutic treatment. [provided by RefSeq, Mar 2017]
View all C8orf34 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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