rs6489882

This is a intron variant variant in the OAS3 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

chronic lymphocytic leukemia

Law PJ et al. “Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia.” Nature Communications 8:14175 (2017)

Allele G

OR 1.16

p 5.0e-8

N 17,691

Large GWAS

European

About OAS3

This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance. [provided by RefSeq, Jul 2008]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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