OAS3
2'-5'-oligoadenylate synthetase 3
Summary
This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance. [provided by RefSeq, Jul 2008]
Known Variants84 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs12302655 | 12:113,374,506 | G/A | downstream gene variant | — |
| rs200540151 | 12:113,376,414 | G/A | — | uncertain significance |
| rs775461414 | 12:113,376,427 | G/A | — | uncertain significance |
| rs2043651566 | 12:113,376,456 | A/T | — | uncertain significance |
| rs756696043 | 12:113,376,459 | G/A | — | uncertain significance |
| rs757631062 | 12:113,376,463 | G/C | — | uncertain significance |
| rs62623451 | 12:113,376,480 | G/A | — | benign |
| rs374238440 | 12:113,376,492 | C/T | — | uncertain significance |
| rs768500059 | 12:113,376,493 | G/A | — | uncertain significance |
| rs1321796242 | 12:113,379,375 | G/A | — | uncertain significance |
| rs745545367 | 12:113,379,478 | G/A | — | uncertain significance |
| rs777901217 | 12:113,379,561 | G/A | — | uncertain significance |
| rs1055619272 | 12:113,379,590 | C/G | — | uncertain significance |
| rs10735079 | 12:113,380,008 | G/C | — | — |
| rs6489882 | 12:113,381,376 | G/A | intron variant | — |
| rs377180136 | 12:113,382,326 | C/T | — | uncertain significance |
| rs45585037 | 12:113,382,355 | G/A | — | uncertain significance |
| rs372942659 | 12:113,382,403 | C/T | — | uncertain significance |
| rs969254961 | 12:113,382,449 | A/G | — | uncertain significance |
| rs1042308839 | 12:113,384,600 | A/G | — | uncertain significance |
| rs1016130048 | 12:113,384,629 | G/A | — | uncertain significance |
| rs775942215 | 12:113,384,737 | G/A | — | uncertain significance |
| rs200065329 | 12:113,384,755 | C/A | — | uncertain significance |
| rs376389899 | 12:113,384,756 | A/G | — | uncertain significance |
| rs1482925657 | 12:113,385,762 | T/C | — | uncertain significance |
| rs745514357 | 12:113,385,782 | T/G | — | uncertain significance |
| rs749442922 | 12:113,385,836 | G/A | — | uncertain significance |
| rs1463299295 | 12:113,386,690 | G/A | — | uncertain significance |
| rs2043760209 | 12:113,386,721 | A/G | — | uncertain significance |
| rs769669888 | 12:113,386,754 | A/G | — | uncertain significance |
| rs189345052 | 12:113,386,765 | C/A | — | uncertain significance |
| rs2285933 | 12:113,386,779 | C/G | — | benign |
| rs2541012516 | 12:113,386,802 | C/T | — | uncertain significance |
| rs888088380 | 12:113,386,882 | C/A | — | uncertain significance |
| rs373103415 | 12:113,386,889 | G/A | — | uncertain significance |
| rs2285932 | 12:113,386,950 | T/C | synonymous variant | — |
| rs1225930669 | 12:113,386,962 | G/C | — | uncertain significance |
| rs760860200 | 12:113,388,498 | G/T | — | uncertain significance |
| rs2541014027 | 12:113,388,505 | C/T | — | uncertain significance |
| rs750291946 | 12:113,388,513 | C/T | — | uncertain significance |
| rs371964344 | 12:113,388,574 | C/T | — | uncertain significance |
| rs115666428 | 12:113,388,598 | G/A | — | benign |
| rs201701503 | 12:113,388,765 | G/T | — | uncertain significance |
| rs200527213 | 12:113,388,766 | C/T | — | uncertain significance |
| rs2072136 | 12:113,398,919 | G/C | synonymous variant | — |
| rs368023053 | 12:113,398,978 | G/A | — | uncertain significance |
| rs760640073 | 12:113,398,991 | G/T | — | uncertain significance |
| rs776201681 | 12:113,398,999 | G/A | — | uncertain significance |
| rs779154930 | 12:113,399,047 | G/A | — | uncertain significance |
| rs371708909 | 12:113,400,461 | C/T | — | uncertain significance |
| rs748049702 | 12:113,400,484 | C/A | — | uncertain significance |
| rs369929424 | 12:113,400,530 | C/G | — | uncertain significance |
| rs559364164 | 12:113,400,589 | C/T | — | uncertain significance |
| rs752543572 | 12:113,400,590 | G/A | — | uncertain significance |
| rs2541021208 | 12:113,400,599 | T/C | — | uncertain significance |
| rs1022085399 | 12:113,400,668 | C/G | — | uncertain significance |
| rs369227720 | 12:113,400,688 | G/A | — | uncertain significance |
| rs1018742530 | 12:113,401,198 | C/G | — | uncertain significance |
| rs45607836 | 12:113,401,212 | G/T | — | benign |
| rs1429034927 | 12:113,401,227 | A/G | — | likely benign |
| rs2541022506 | 12:113,402,070 | G/A | — | uncertain significance |
| rs1300917637 | 12:113,402,185 | C/A | — | uncertain significance |
| rs760359985 | 12:113,403,585 | C/T | — | uncertain significance |
| rs756226307 | 12:113,403,628 | A/T | — | uncertain significance |
| rs768126336 | 12:113,403,753 | G/A | — | uncertain significance |
| rs2541023770 | 12:113,403,780 | A/G | — | uncertain significance |
| rs550945075 | 12:113,403,781 | C/T | — | uncertain significance |
| rs372847671 | 12:113,403,786 | C/G | — | uncertain significance |
| rs201089820 | 12:113,403,827 | C/A | — | uncertain significance |
| rs757900425 | 12:113,405,307 | C/T | — | uncertain significance |
| rs778569916 | 12:113,405,319 | A/G | — | uncertain significance |
| rs200185349 | 12:113,405,372 | C/T | — | uncertain significance |
| rs1354602189 | 12:113,405,759 | G/A | — | uncertain significance |
| rs775639349 | 12:113,405,804 | G/A | — | uncertain significance |
| rs201783757 | 12:113,405,891 | C/T | — | uncertain significance |
| rs372426187 | 12:113,405,892 | G/A | — | uncertain significance |
| rs545617712 | 12:113,405,927 | G/A | — | likely benign |
| rs200315889 | 12:113,405,966 | C/A | — | uncertain significance |
| rs377674867 | 12:113,407,439 | C/T | — | uncertain significance |
| rs370242461 | 12:113,407,526 | G/A | — | uncertain significance |
| rs774833836 | 12:113,407,534 | A/G | — | uncertain significance |
| rs768005102 | 12:113,407,549 | T/C | — | uncertain significance |
| rs766200139 | 12:113,407,770 | G/C | — | uncertain significance |
| rs2072134 | 12:113,409,176 | G/A | regulatory region variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.