rs2072134
This is a regulatory region variant variant in the OAS3 gene.
▶GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
high density lipoprotein cholesterol measurement
Graham SE et al. “The power of genetic diversity in genome-wide association studies of lipids.” Nature 600(7890):675-679 (2021)
Allele A
OR 0.06
p 1.0e-23
N 146,492
Large GWAS
East Asian
Lee SB et al. “Dyslipidaemia-Genotype Interactions with Nutrient Intake and Cerebro-Cardiovascular Disease.” Biomedicines 10(7) (2022)
Allele A
OR 1.08
p 1.0e-20
N 58,701
Large GWAS
East Asian
Liu M et al. “Protein and fat intake interacts with the haplotype of PTPN11_rs11066325, RPH3A_rs886477, and OAS3_rs2072134 to modulate serum HDL concentrations in middle-aged people.” Clinical Nutrition (edinburgh, Scotland) 39(3):942-949 (2020)
Allele A
OR 1.36
p 6.0e-12
N 8,839
Large GWAS
East Asian
alcohol drinking
Baik I et al. “Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men.” The American Journal of Clinical Nutrition 93(4):809-16 (2011)
Allele A
OR 0.61
p 6.0e-17
N 1,721
Large GWAS
East Asian
alcohol consumption quality, alcohol drinking
Jorgenson E et al. “Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study.” Molecular Psychiatry 22(9):1359-1367 (2017)
Allele A
OR 1.58
p 3.0e-16
N 86,627
Large GWAS
multi-ancestry
hypertension
Jeong H et al. “Identifying Interactions between Dietary Sodium, Potassium, Sodium-Potassium Ratios, and FGF5 rs16998073 Variants and Their Associated Risk for Hypertension in Korean Adults.” Nutrients 12(7) (2020)
Allele A
OR 0.78
p 1.0e-10
N 17,736
Large GWAS
East Asian
body height
Chiou JS et al. “Your height affects your health: genetic determinants and health-related outcomes in Taiwan.” Bmc Medicine 20(1):250 (2022)
Allele G
OR 0.04
p 2.0e-9
N 67,452
Large GWAS
East Asian
About OAS3
This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance. [provided by RefSeq, Jul 2008]
View all OAS3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
Community Wiki
No community notes yet for this variant. Sign in to start one.
Comments
Sign in to join the discussion.
Loading comments…