rs6505765

This is a regulatory region variant variant.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Thyroid preparation use measurement

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele G

OR 0.08

p 3.0e-17

N 484,308

Large GWAS

multi-ancestry

Wu Y et al. “Genome-wide association study of medication-use and associated disease in the UK Biobank.” Nature Communications 10(1):1891 (2019)

Allele G

OR 0.08

p 3.0e-15

N 305,582

Major Consortium StudyLarge GWAS

European

autoimmune thyroid disease

Saevarsdottir S et al. “FLT3 stop mutation increases FLT3 ligand level and risk of autoimmune thyroid disease.” Nature 584(7822):619-623 (2020)

Allele G

OR 1.07

p 2.0e-11

N 754,406

Large GWAS

European

Zeng Y et al. “Genetic Associations Between Stress-Related Disorders and Autoimmune Disease.” The American Journal of Psychiatry 180(4):294-304 (2023)

Allele G

OR 1.06

p 4.0e-9

N 376,871

Large GWAS

European

hypothyroidism

White SL et al. “Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases.” Nature Genetics 58(2):307-316 (2026)

Allele G

OR 0.04

p 7.0e-22

N 1,786,062

Large GWAS

European

Rand SA et al. “Genome-wide association study and polygenic risk prediction of hypothyroidism.” Nature Genetics 57(12):3007-3015 (2025)

Allele G

OR 0.04

p 3.0e-17

N 1,178,661

Large GWAS

European

Mathieu S et al. “Genetic association and Mendelian randomization for hypothyroidism highlight immune molecular mechanisms.” Iscience 25(9):104992 (2022)

Allele G

OR 0.06

p 1.0e-11

N 494,577

Large GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

rs6505765

GWAS Catalog Trait Associations (3)

Thyroid preparation use measurement

autoimmune thyroid disease

hypothyroidism

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