rs6734238

This is a upstream gene variant variant.

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GWAS Catalog Trait Associations (41)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

interleukin 1 receptor antagonist measurement

Folkersen L et al. “Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals.” Nature Metabolism 2(10):1135-1148 (2020)

Allele A

OR 0.21

p 3.0e-110

N 21,758

Large GWAS

European

Meeks KAC et al. “Genome-wide analyses of multiple obesity-related cytokines and hormones informs biology of cardiometabolic traits.” Genome Medicine 13(1):156 (2021)

Allele A

OR 0.18

p 2.0e-9

N 2,222

Large GWAS

multi-ancestry

C-reactive protein measurement

Said S et al. “Genetic analysis of over half a million people characterises C-reactive protein loci.” Nature Communications 13(1):2198 (2022)

Allele G

OR 0.04

p 1.0e-107

N 575,531

Large GWAS

European

Ligthart S et al. “Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders.” American Journal of Human Genetics 103(5):691-706 (2018)

Allele G

OR 0.05

p 6.0e-38

N 148,164

Large GWAS

European

Dehghan A et al. “Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.” Circulation 123(7):731-8 (2011)

Allele G

OR 0.05

p 2.0e-17

N 66,185

Meta-analysisLarge GWAS

European

Jiang MZ et al. “Whole genome sequencing based analysis of inflammation biomarkers in the Trans-Omics for Precision Medicine (TOPMed) consortium.” Human Molecular Genetics 33(16):1429-1441 (2024)

Allele G

OR 0.07

p 5.0e-16

N 38,465

Major Consortium StudyLarge GWAS

multi-ancestry

Reiner AP et al. “Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.” American Journal of Human Genetics 91(3):502-12 (2012)

Allele G

OR 0.11

p 9.0e-10

N 11,828

Large GWAS

multi-ancestry

neutrophil count

Chen MH et al. “Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.” Cell 182(5):1198-1213.e14 (2020)

Allele G

OR —

p 2.0e-96

N 627,215

Large GWAS

multi-ancestry

Vuckovic D et al. “The Polygenic and Monogenic Basis of Blood Traits and Diseases.” Cell 182(5):1214-1231.e11 (2020)

Allele G

OR 0.03

p 8.0e-51

N 408,112

Large GWAS

European

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.05

p 1.0e-55

N 261,847

Major Consortium StudyLarge GWAS

European

Kachuri L et al. “Genetic determinants of blood-cell traits influence susceptibility to childhood acute lymphoblastic leukemia.” American Journal of Human Genetics 108(10):1823-1835 (2021)

Allele G

OR —

p 4.0e-31

N 234,802

Large GWAS

European

myeloid leukocyte count

Chen MH et al. “Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.” Cell 182(5):1198-1213.e14 (2020)

Allele G

OR —

p 2.0e-80

N 746,667

Large GWAS

multi-ancestry

circulating fibrinogen levels

de Vries PS et al. “A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration.” Human Molecular Genetics 25(2):358-70 (2016)

Allele G

OR —

β 0.011

p 7.0e-30

N 120,246

Meta-analysisLarge GWAS

European

Sabater-Lleal M et al. “Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.” Circulation 128(12):1310-24 (2013)

Allele G

OR 0.01

p 6.0e-19

N 91,323

Meta-analysisLarge GWAS

multi-ancestry

serum albumin amount

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele G

OR 0.02

p 2.0e-29

N 450,015

Large GWAS

multi-ancestry

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.02

p 5.0e-22

N 542,272

Major Consortium StudyLarge GWAS

multi-ancestry

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele G

OR 0.02

p 2.0e-10

N 435,807

Large GWAS

multi-ancestry

Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)

Allele G

OR 0.02

p 5.0e-9

N 115,064

Large GWAS

European

serum alanine aminotransferase amount

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele A

OR 0.03

p 4.0e-28

N 583,982

Major Consortium StudyLarge GWAS

multi-ancestry

Vujkovic M et al. “A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation.” Nature Genetics 54(6):761-771 (2022)

Allele A

OR 0.06

p 5.0e-19

N 218,595

Large GWAS

multi-ancestry

glycoprotein measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele G

OR 0.02

p 9.0e-28

N 450,015

Large GWAS

multi-ancestry

Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)

Allele G

OR 0.02

p 3.0e-9

N 115,082

Large GWAS

European

aspartate aminotransferase to alanine aminotransferase ratio

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele A

OR 0.02

p 4.0e-22

N 561,715

Major Consortium StudyLarge GWAS

multi-ancestry

aspartate aminotransferase measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele G

OR 0.02

p 5.0e-22

N 394,642

Large GWAS

European

Chen VL et al. “Genome-wide association study of serum liver enzymes implicates diverse metabolic and liver pathology.” Nature Communications 12(1):816 (2021)

Allele G

OR 8.10

p 5.0e-16

N 389,565

Large GWAS

multi-ancestry

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Research that mentions this SNP (1)

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Genome-wide associated loci influencing interleukin (IL)-10, IL-1Ra, and IL-6 levels in African Americans

AssociationN=707Fasil Tekola Ayele et al.(2012)· Immunogenetics

This genome-wide association study (GWAS) identified genetic variants influencing interleukin levels in African Americans. IL-10 levels showed genome-wide significant associations with 8 SNPs, most notably rs5743185 in PMS1 (p=2.30×10⁻¹⁰), with successful replication of rs17365948 in YWHAZ. IL-1Ra levels showed suggestive associations with SNPs in ASB3 and the IL-1 gene family, with replication of rs4251961. IL-6 levels showed genome-wide significant association with one variant near RP11-314E23.1 (p=8.63×10⁻⁹).

Traits studied:Interleukin-10 (IL-10) levelsInterleukin-1Ra (IL-1Ra) levelsInterleukin-6 (IL-6) levelsPlasma cytokine levels

PubMed DOI Metascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

rs6734238

GWAS Catalog Trait Associations (41)

interleukin 1 receptor antagonist measurement

C-reactive protein measurement

neutrophil count

myeloid leukocyte count

circulating fibrinogen levels

serum albumin amount

serum alanine aminotransferase amount

glycoprotein measurement

aspartate aminotransferase to alanine aminotransferase ratio

aspartate aminotransferase measurement

Research that mentions this SNP (1)

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