rs6875372

This is a intron variant variant in the CWC27 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

pulse pressure measurement

Keaton JM et al. “Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.” Nature Genetics 56(5):778-791 (2024)

Allele A

OR 0.11

p 3.0e-10

N 1,028,980

Large GWAS

multi-ancestry

systolic blood pressure

Evangelou E et al. “Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.” Nature Genetics 50(10):1412-1425 (2018)

Allele T

OR 0.19

p 5.0e-10

N 757,601

Large GWAS

European

Allele T

OR 0.14

p 2.0e-8

N 1,028,980

Large GWAS

multi-ancestry

About CWC27

Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Located in nucleoplasm. Part of U2-type precatalytic spliceosome and catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Jul 2025]

View all CWC27 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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