CWC27
CWC27 spliceosome associated cyclophilin
Summary
Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Located in nucleoplasm. Part of U2-type precatalytic spliceosome and catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants296 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1363953 | 5:64,064,943 | G/A | — | benign |
| rs758537226 | 5:64,064,983 | A/G | — | uncertain significance |
| rs746999665 | 5:64,064,989 | A/G | — | uncertain significance |
| rs138792608 | 5:64,064,993 | A/C | — | uncertain significance |
| rs529010023 | 5:64,065,005 | C/T | — | uncertain significance |
| rs774206993 | 5:64,065,006 | G/A | — | likely benign |
| rs1743147822 | 5:64,065,016 | G/A | — | likely pathogenic |
| rs771558152 | 5:64,065,023 | C/T | — | likely benign |
| rs760062719 | 5:64,065,031 | A/G | — | likely benign |
| rs1743378434 | 5:64,070,500 | G/T | — | likely benign |
| rs376182212 | 5:64,070,518 | G/A | — | uncertain significance |
| rs369814947 | 5:64,070,524 | T/C | — | likely benign |
| rs1743379298 | 5:64,070,528 | A/G | — | uncertain significance |
| rs1743379463 | 5:64,070,531 | C/G | — | uncertain significance |
| rs1012208400 | 5:64,070,535 | A/C | — | likely benign |
| rs781194080 | 5:64,070,546 | T/C | — | uncertain significance |
| rs2112143355 | 5:64,070,551 | A/C | — | uncertain significance |
| rs1040435835 | 5:64,070,561 | G/C | — | uncertain significance |
| rs922927440 | 5:64,070,569 | G/T | — | pathogenic |
| rs929067484 | 5:64,070,574 | T/C | — | likely benign |
| rs141974787 | 5:64,070,575 | C/A | — | uncertain significance |
| rs201232840 | 5:64,070,596 | A/C | — | uncertain significance |
| rs1260666125 | 5:64,070,604 | T/C | — | likely benign |
| rs1267513694 | 5:64,070,627 | T/C | — | likely benign |
| rs1580576759 | 5:64,070,632 | C/A | — | likely benign |
| rs7701842 | 5:64,074,730 | A/T | intron variant | — |
| rs9291822 | 5:64,076,515 | C/T | intron variant | — |
| rs543303233 | 5:64,077,735 | A/T | — | likely benign |
| rs368081814 | 5:64,077,748 | C/A | — | uncertain significance |
| rs370593428 | 5:64,077,751 | A/G | — | uncertain significance |
| rs1368981497 | 5:64,077,759 | A/C | — | uncertain significance |
| rs745426383 | 5:64,077,783 | C/T | — | uncertain significance |
| rs1443869672 | 5:64,077,797 | C/G | — | likely benign |
| rs749180749 | 5:64,077,803 | C/T | — | likely benign |
| rs753398778 | 5:64,077,804 | G/A | — | uncertain significance |
| rs532275928 | 5:64,077,810 | C/T | — | uncertain significance |
| rs1743710379 | 5:64,077,811 | C/T | — | uncertain significance |
| rs1743710958 | 5:64,077,815 | T/A | — | likely benign |
| rs2112161150 | 5:64,077,820 | C/A | — | uncertain significance |
| rs1208853313 | 5:64,077,827 | T/G | — | uncertain significance |
| rs776705210 | 5:64,077,843 | T/A | — | uncertain significance |
| rs373067401 | 5:64,077,844 | A/G | — | uncertain significance |
| rs1377145480 | 5:64,077,846 | G/A | — | uncertain significance |
| rs765721927 | 5:64,077,850 | C/T | — | uncertain significance |
| rs753031106 | 5:64,077,851 | G/A | — | likely benign |
| rs1444332691 | 5:64,077,858 | A/G | — | uncertain significance |
| rs1468432566 | 5:64,077,861 | G/A | — | likely pathogenic |
| rs2112161353 | 5:64,077,869 | G/A | — | likely benign |
| rs6875372 | 5:64,079,015 | T/A | intron variant | — |
| rs759616532 | 5:64,079,645 | A/C | — | benign |
| rs2112165600 | 5:64,079,655 | C/T | — | likely benign |
| rs1433799113 | 5:64,079,665 | T/A | — | uncertain significance |
| rs138235746 | 5:64,079,675 | T/C | — | uncertain significance |
| rs1238819839 | 5:64,079,678 | C/T | — | uncertain significance |
| rs377331761 | 5:64,079,684 | C/T | — | uncertain significance |
| rs568150813 | 5:64,079,685 | G/A | — | uncertain significance |
| rs753319511 | 5:64,079,691 | A/C | — | uncertain significance |
| rs370669132 | 5:64,079,694 | G/A | — | uncertain significance |
| rs2531260921 | 5:64,079,699 | G/A | — | uncertain significance |
| rs2112165858 | 5:64,079,709 | C/T | — | uncertain significance |
| rs375560494 | 5:64,079,711 | A/G | — | uncertain significance |
| rs752677043 | 5:64,079,714 | G/A | — | uncertain significance |
| rs2531261009 | 5:64,079,719 | T/C | — | likely benign |
| rs777723083 | 5:64,079,736 | A/G | — | uncertain significance |
| rs2531261098 | 5:64,079,737 | T/C | — | likely benign |
| rs566171437 | 5:64,079,738 | G/A | — | uncertain significance |
| rs771085707 | 5:64,079,740 | C/T | — | likely benign |
| rs199984122 | 5:64,079,763 | G/T | — | uncertain significance |
| rs1186944777 | 5:64,079,765 | C/T | — | pathogenic |
| rs149610828 | 5:64,079,766 | G/A | — | uncertain significance |
| rs762125859 | 5:64,079,782 | C/G | — | uncertain significance |
| rs2531261271 | 5:64,079,787 | A/G | — | uncertain significance |
| rs764988150 | 5:64,079,811 | G/T | — | uncertain significance |
| rs1743794348 | 5:64,079,812 | T/C | — | uncertain significance |
| rs752194798 | 5:64,079,816 | C/T | — | likely benign |
| rs1580591733 | 5:64,079,817 | A/G | — | likely benign |
| rs2531261374 | 5:64,079,825 | T/C | — | likely benign |
| rs553627965 | 5:64,081,292 | A/G | — | likely benign |
| rs2531264405 | 5:64,081,296 | T/C | — | likely benign |
| rs2112169750 | 5:64,081,307 | G/A | — | likely pathogenic |
| rs774808999 | 5:64,081,316 | G/T | — | likely benign |
| rs1743849689 | 5:64,081,324 | T/C | — | uncertain significance |
| rs762134607 | 5:64,081,325 | A/G | — | likely benign |
| rs773382223 | 5:64,081,338 | C/T | — | pathogenic |
| rs764747161 | 5:64,081,343 | G/A | — | likely benign |
| rs764172645 | 5:64,081,360 | A/G | — | uncertain significance |
| rs373443413 | 5:64,081,367 | C/T | — | likely benign |
| rs114765726 | 5:64,081,368 | G/A | — | likely benign |
| rs2531264728 | 5:64,081,372 | G/A | — | uncertain significance |
| rs1239709056 | 5:64,081,377 | C/T | — | uncertain significance |
| rs2112170031 | 5:64,081,382 | T/C | — | likely benign |
| rs368541156 | 5:64,081,387 | A/T | — | uncertain significance |
| rs2531264803 | 5:64,081,390 | A/G | — | uncertain significance |
| rs989567504 | 5:64,081,392 | A/G | — | uncertain significance |
| rs1323531999 | 5:64,081,395 | A/G | — | uncertain significance |
| rs1085307446 | 5:64,081,406 | G/A | splice region variant | pathogenic |
| rs371394386 | 5:64,081,410 | G/C | — | uncertain significance |
| rs1411793658 | 5:64,081,421 | A/G | — | likely benign |
| rs201304417 | 5:64,081,425 | C/T | — | likely benign |
| rs755029729 | 5:64,081,426 | G/A | — | likely benign |
Showing 100 of 296 variants. Use the SNP search for the full list.
Gene information from NCBI Gene. Variant classifications from ClinVar.