rs6914598

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

cutaneous melanoma

Landi MT et al. “Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility.” Nature Genetics 52(5):494-504 (2020)

Allele C

OR 1.10

p 1.0e-18

N 411,948

Large GWAS

European

Liyanage UE et al. “Multi-Trait Genetic Analysis Identifies Autoimmune Loci Associated with Cutaneous Melanoma.” The Journal of Investigative Dermatology 142(6):1607-1616 (2022)

Allele C

OR 0.05

p 3.0e-11

N 380,287

Large GWAS

European

Law MH et al. “Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma.” Nature Genetics 47(9):987-995 (2015)

Allele C

OR 0.10

p 4.0e-8

N 36,077

Meta-analysisLarge GWAS

European

nevus count, cutaneous melanoma

Landi MT et al. “Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility.” Nature Genetics 52(5):494-504 (2020)

Allele T

OR —

p 3.0e-12

N 477,725

Large GWAS

European

melanoma

Ransohoff KJ et al. “Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma.” Oncotarget 8(11):17586-17592 (2017)

Allele C

OR 1.10

p 4.0e-8

N 291,407

Large GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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