rs7029757

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

serum alanine aminotransferase amount

Ghouse J et al. “Integrative common and rare variant analyses provide insights into the genetic architecture of liver cirrhosis.” Nature Genetics 56(5):827-837 (2024)
Allele A
OR 0.01
p 8.0e-18
N 1,010,710
Large GWAS
European
Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)
Allele A
OR 0.02
p 1.0e-17
N 928,679
Large GWAS
multi-ancestry
Pazoki R et al. “Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes.” Nature Communications 12(1):2579 (2021)
Allele A
OR 0.01
p 1.0e-15
N 437,267
Large GWAS
European
Chen VL et al. “Genome-wide association study of serum liver enzymes implicates diverse metabolic and liver pathology.” Nature Communications 12(1):816 (2021)
Allele A
OR 5.60
p 2.0e-8
N 390,812
Large GWAS
multi-ancestry
Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)
Allele A
OR 0.03
p 8.0e-11
N 355,729
Major Consortium StudyLarge GWAS
multi-ancestry

non-alcoholic fatty liver disease

Chen Y et al. “Genome-wide association meta-analysis identifies 17 loci associated with nonalcoholic fatty liver disease.” Nature Genetics 55(10):1640-1650 (2023)
Allele G
OR 6.68
p 2.0e-11
N 691,479
Meta-analysisLarge GWAS
South Asian, European, African American or Afro-Caribbean, East Asian, Hispanic or Latin American

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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