rs705700
This is a regulatory region variant variant in the RAB5B gene.
▶GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
asthma
Ferreira MAR et al. “Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.” American Journal of Human Genetics 104(4):665-684 (2019)
Allele C
OR 1.07
p 4.0e-23
N 341,215
Large GWAS
European
Zhu Z et al. “Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis.” The European Respiratory Journal 54(6) (2019)
Allele C
OR 1.05
p 1.0e-16
N 394,283
Large GWAS
multi-ancestry
Jia G et al. “Discerning asthma endotypes through comorbidity mapping.” Nature Communications 13(1):6712 (2022)
Allele C
OR 1.05
p 3.0e-12
N 305,098
Large GWAS
multi-ancestry
rheumatoid arthritis
Ishigaki K et al. “Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis.” Nature Genetics 54(11):1640-1651 (2022)
Allele C
OR 0.93
p 1.0e-11
N 276,020
Large GWAS
multi-ancestry
rheumatoid arthritis, anti-citrullinated protein antibody seropositivity, rheumatoid factor seropositivity measurement
Ishigaki K et al. “Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis.” Nature Genetics 54(11):1640-1651 (2022)
Allele C
OR 0.93
p 4.0e-10
N 267,597
Large GWAS
multi-ancestry
blood immunoglobulin amount
Wei Y et al. “Genome-wide association studies of thyroid-related hormones, dysfunction, and autoimmunity among 85,421 Chinese pregnancies.” Nature Communications 15(1):8004 (2024)
Allele C
OR 0.14
p 1.0e-9
N 60,225
Large GWAS
East Asian
About RAB5B
Enables GDP binding activity; GTP-dependent protein binding activity; and GTPase activity. Involved in antigen processing and presentation and plasma membrane to endosome transport. Located in endosome and extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
View all RAB5B variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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