rs7110736

This variant is located in the TMPRSS5 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

substance-related disorder

Lai D et al. “Genome-wide meta-analyses of cross substance use disorders in diverse populations.” Molecular Psychiatry 31(3):1619-1633 (2026)

Allele A

OR 6.22

p 5.0e-10

N 1,517,369

Large GWAS

multi-ancestry

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ClinVar annotation

Benign★★★☆

2 submitters1 publication

not specified; not provided

View on ClinVar →

About TMPRSS5

This gene encodes a protein that belongs to the serine protease family. Serine proteases are known to be involved in many physiological and pathological processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

View all TMPRSS5 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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