TMPRSS5

transmembrane serine protease 5

Summary

This gene encodes a protein that belongs to the serine protease family. Serine proteases are known to be involved in many physiological and pathological processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Known Variants90 total

rsidPosition (GRCh37)AllelesClassClinVar
rs658939111:113,557,891C/Tdownstream gene variant—
rs1711582611:113,558,845A/G—benign
rs11620543211:113,558,890G/A—likely benign
rs11493001011:113,559,051G/A—likely benign
rs11582577011:113,560,477C/T—benign
rs213478058811:113,560,581A/C—uncertain significance
rs74556944011:113,560,586C/T—likely benign
rs77174668911:113,560,593C/T—likely benign
rs76764191911:113,560,906A/C—benign
rs75326745211:113,560,912A/C—benign
rs75420299111:113,560,918A/C—benign
rs20040488811:113,560,969C/T—conflicting classifications of pathogenicity
rs20142238711:113,560,988C/A—likely benign
rs74911044111:113,561,000G/A—conflicting classifications of pathogenicity
rs7948057911:113,561,001G/A—likely benign
rs11557713711:113,561,016G/A—benign
rs1121470311:113,561,025G/A—benign
rs254704107911:113,561,047G/C—uncertain significance
rs711073611:113,561,054A/G—benign
rs711073811:113,561,057A/G—benign
rs55445127911:113,561,067C/G—likely benign
rs131077957011:113,561,079C/T—uncertain significance
rs1160143511:113,561,247T/C—benign
rs1160759111:113,561,256G/A—benign
rs711419511:113,561,421A/C—benign
rs36758623811:113,561,605G/A—uncertain significance
rs18624411411:113,561,609G/A—likely benign
rs11705569211:113,561,650C/A—likely benign
rs1160769011:113,561,727G/A—benign
rs7682471811:113,561,780C/T—benign
rs55445645811:113,562,632C/A——
rs1121470611:113,563,559A/C—benign
rs1121470711:113,563,560C/G—benign
rs1121470811:113,563,574T/A—benign
rs1160460211:113,563,688A/G—benign
rs53652101611:113,563,829C/T—uncertain significance
rs37681299611:113,563,870G/A—uncertain significance
rs124657105411:113,563,877T/A—uncertain significance
rs78032472111:113,563,910C/T—uncertain significance
rs115676149211:113,563,918T/G—uncertain significance
rs131311534411:113,563,936T/C—uncertain significance
rs37124312911:113,563,975C/T—likely benign
rs1160057011:113,564,012G/A—benign
rs20041767411:113,565,234G/A—benign
rs6199594411:113,565,238T/C—benign
rs20111139711:113,565,252C/T—conflicting classifications of pathogenicity
rs11691328211:113,565,260G/A—likely benign
rs99826914011:113,565,279C/T—uncertain significance
rs1711584111:113,565,322C/A—benign
rs6199594511:113,565,353G/A—likely benign
rs159138001411:113,566,143C/T—likely benign
rs20050760111:113,566,152A/T—likely benign
rs4551519911:113,566,205C/T—benign
rs493627911:113,566,207C/A—benign
rs4550369911:113,566,327C/A—benign
rs56569243111:113,567,620G/A—uncertain significance
rs195294246211:113,567,622G/A—uncertain significance
rs78025101311:113,567,669G/T—uncertain significance
rs11560426911:113,567,699C/T—benign
rs195295623311:113,568,021T/C—uncertain significance
rs37180354811:113,568,081G/A—uncertain significance
rs793991711:113,568,096C/T—benign
rs77625264311:113,568,121G/T—uncertain significance
rs1089158711:113,569,575T/G—benign
rs77919731911:113,569,735G/A—uncertain significance
rs1279765411:113,569,933G/C—benign
rs53080066411:113,569,937C/G—benign
rs79674054411:113,569,959C/G—benign
rs86870730311:113,569,968T/C—benign
rs1121470911:113,569,982T/C—benign
rs7356880811:113,570,208C/T—benign
rs37588879711:113,570,328G/A—uncertain significance
rs36895909111:113,570,344C/T—uncertain significance
rs6132662611:113,570,360G/A—benign
rs14381698411:113,570,383G/A—likely benign
rs1160142511:113,570,385C/T—benign
rs77191726311:113,570,395G/A—likely benign
rs493628011:113,570,405C/T—benign
rs4555033111:113,570,470A/G—likely benign
rs380285611:113,570,490T/C—benign
rs11531281811:113,570,515C/T—likely benign
rs57166630411:113,570,679C/T—likely benign
rs20084500211:113,570,752C/Tintron variant—
rs380285411:113,570,852C/T—benign
rs37254074811:113,570,863T/C—likely benign
rs11625596311:113,576,902G/C—likely benign
rs792626711:113,576,932A/G—benign
rs7663364611:113,576,997C/T—likely benign
rs7564894411:113,577,032G/T—benign
rs4561813411:113,578,393A/Gupstream gene variant—

Gene information from NCBI Gene. Variant classifications from ClinVar.