rs7130881

This variant is located in the LOC105369367 gene.

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GWAS Catalog Trait Associations (5)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

prostate carcinoma

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.24
p 4.0e-156
N 573,692
Major Consortium StudyLarge GWAS
multi-ancestry
Schumacher FR et al. “Genome-wide association study identifies new prostate cancer susceptibility loci.” Human Molecular Genetics 20(19):3867-75 (2011)
Allele A
OR 1.31
p 9.0e-9
N 7,240
Large GWAS
European

prostate specific antigen amount

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.15
p 6.0e-21
N 100,875
Major Consortium StudyLarge GWAS
African American or Afro-Caribbean

prostate cancer

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.25
p 7.0e-20
N 48,011
Major Consortium StudyLarge GWAS
African American or Afro-Caribbean

family history of prostate cancer

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.08
p 5.0e-12
N 315,668
Major Consortium StudyLarge GWAS
European

cancer

Ahmed M et al. “Considering hormone-sensitive cancers as a single disease in the UK biobank reveals shared aetiology.” Communications Biology 5(1):614 (2022)
Allele G
OR —
β 0.004
p 3.0e-9
N 230,245
Major Consortium StudyLarge GWAS
European
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Research that mentions this SNP (1)

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Genetic ancestry and prostate cancer susceptibility SNPs in Puerto Rican and African American men
AssociationN=831Margarita Irizarry‐Ramírez et al.(2017)· The Prostate

This case-control study examined the association between West African ancestry (WAA) and prostate cancer (PCa) risk and aggressiveness in 291 Puerto Rican (PR) and 200 African American (AA) cases versus 133 PR and 207 AA controls. The SNP rs7824364 at chromosome 8q24 was significantly associated with PCa in both populations (p<0.0001 for AA, p=0.0001 for PR), with 82% of AA cases and 41% of PR cases carrying 1-2 risk alleles. Among PR men, those with the rs7824364 risk allele showed elevated WAA (39% versus 29%, p=0.034). No direct association between WAA and PCa aggressiveness was found.

Traits studied:Prostate cancerProstate cancer aggressiveness
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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