rs72654473
This is a regulatory region variant variant.
▶GWAS Catalog Trait Associations (29)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (29)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
low density lipoprotein cholesterol measurement
Choe EK et al. “Leveraging deep phenotyping from health check-up cohort with 10,000 Korean individuals for phenome-wide association study of 136 traits.” Scientific Reports 12(1):1930 (2022)
Allele A
OR 18.46
p 3.0e-98
N 9,635
Large GWAS
East Asian
Jeon S et al. “Korea4K: whole genome sequences of 4,157 Koreans with 107 phenotypes derived from extensive health check-ups.” Gigascience 13 (2024)
Allele A
OR 0.53
p 2.0e-15
N 2,297
Large GWAS
East Asian
Huang S et al. “The Born in Guangzhou Cohort Study enables generational genetic discoveries.” Nature 626(7999):565-573 (2024)
Allele A
OR —
β 0.793
p 5.0e-39
N 1,532
Large GWAS
East Asian
protein measurement
Pietzner M et al. “Mapping the proteo-genomic convergence of human diseases.” Science (new York, N.y.) 374(6569):eabj1541 (2021)
Allele A
OR 0.41
p 1.0e-82
N 10,708
Large GWAS
European
cholesteryl ester measurement
Davyson E et al. “Metabolomic Investigation of Major Depressive Disorder Identifies a Potentially Causal Association With Polyunsaturated Fatty Acids.” Biological Psychiatry 94(8):630-639 (2023)
Allele A
OR 0.14
p 2.0e-81
N 88,329
Large GWAS
European
omega-6:omega-3 polyunsaturated fatty acid ratio
Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele A
OR 0.06
p 2.0e-76
N 450,015
Large GWAS
multi-ancestry
anxiety measurement, low density lipoprotein cholesterol measurement
Bentley AR et al. “Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids.” Translational Psychiatry 15(1):207 (2025)
Allele A
OR —
β 1.966
p 4.0e-74
N 89,939
Large GWAS
European
total cholesterol measurement
Huang S et al. “The Born in Guangzhou Cohort Study enables generational genetic discoveries.” Nature 626(7999):565-573 (2024)
Allele A
OR —
β 0.463
p 3.0e-67
N 1,535
Large GWAS
East Asian
Choe EK et al. “Leveraging deep phenotyping from health check-up cohort with 10,000 Korean individuals for phenome-wide association study of 136 traits.” Scientific Reports 12(1):1930 (2022)
Allele A
OR 10.39
p 2.0e-25
N 9,710
Large GWAS
East Asian
Jeon S et al. “Korea4K: whole genome sequences of 4,157 Koreans with 107 phenotypes derived from extensive health check-ups.” Gigascience 13 (2024)
Allele A
OR 0.37
p 2.0e-8
N 2,343
Large GWAS
East Asian
triglycerides in very small VLDL measurement
Davyson E et al. “Metabolomic Investigation of Major Depressive Disorder Identifies a Potentially Causal Association With Polyunsaturated Fatty Acids.” Biological Psychiatry 94(8):630-639 (2023)
Allele A
OR 0.12
p 4.0e-59
N 88,329
Large GWAS
European
triglycerides to phosphoglycerides ratio
Davyson E et al. “Metabolomic Investigation of Major Depressive Disorder Identifies a Potentially Causal Association With Polyunsaturated Fatty Acids.” Biological Psychiatry 94(8):630-639 (2023)
Allele A
OR 0.11
p 3.0e-51
N 88,268
Large GWAS
European
cholesteryl esters:total lipids ratio, blood VLDL cholesterol amount
Karjalainen MK et al. “Genome-wide characterization of circulating metabolic biomarkers.” Nature 628(8006):130-138 (2024)
Allele A
OR 0.09
p 2.0e-36
N 136,016
Large GWAS
multi-ancestry
gastrin-releasing peptide measurement
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele A
OR 0.09
p 1.0e-25
N 47,745
Large GWAS
European
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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