rs72805692

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GWAS Catalog Trait Associations (20)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

hemoglobin measurement

Chen MH et al. “Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.” Cell 182(5):1198-1213.e14 (2020)

Allele G

OR 0.14

p —

N 563,946

Large GWAS

European

Hu Y et al. “Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program.” American Journal of Human Genetics 108(5):874-893 (2021)

Allele G

OR 0.13

p 3.0e-25

N 62,461

Large GWAS

multi-ancestry

Akbari P et al. “A genome-wide association study of blood cell morphology identifies cellular proteins implicated in disease aetiology.” Nature Communications 14(1):5023 (2023)

Allele G

OR 0.09

p 2.0e-17

N 38,553

Large GWAS

European

HbA1c measurement

Downie CG et al. “Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study.” Diabetologia 65(3):477-489 (2022)

Allele A

OR 0.26

p 5.0e-44

N 23,357

Large GWAS

European, African American or Afro-Caribbean, Hispanic or Latin American, Asian unspecified

Chen J et al. “The trans-ancestral genomic architecture of glycemic traits.” Nature Genetics 53(6):840-860 (2021)

Allele A

OR —

β 0.086

p 2.0e-22

N 15,248

Large GWAS

Hispanic or Latin American

Moon JY et al. “A Genome-Wide Association Study Identifies Blood Disorder-Related Variants Influencing Hemoglobin A(1c) With Implications for Glycemic Status in U.S. Hispanics/Latinos.” Diabetes Care 42(9):1784-1791 (2019)

Allele A

OR 0.10

p 6.0e-26

N 9,636

Large GWAS

Hispanic or Latin American

lactate measurement

Nemkov T et al. “Biological and genetic determinants of glycolysis: Phosphofructokinase isoforms boost energy status of stored red blood cells and transfusion outcomes.” Cell Metabolism 36(9):1979-1997.e13 (2024)

Allele G

OR 0.23

p 7.0e-29

N 11,334

Large GWAS

multi-ancestry

erythrocyte attribute

Akbari P et al. “A genome-wide association study of blood cell morphology identifies cellular proteins implicated in disease aetiology.” Nature Communications 14(1):5023 (2023)

Allele G

OR 0.12

p 1.0e-26

N 39,313

Large GWAS

European

hematocrit

Hu Y et al. “Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program.” American Journal of Human Genetics 108(5):874-893 (2021)

Allele G

OR 0.39

p 5.0e-26

N 62,487

Large GWAS

multi-ancestry

kell blood group glycoprotein measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele G

OR 0.06

p 3.0e-16

N 47,745

Large GWAS

European

lipoprotein measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele G

OR 0.02

p 4.0e-14

N 450,015

Large GWAS

multi-ancestry

sphingomyelin measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele G

OR 0.02

p 4.0e-14

N 450,015

Large GWAS

multi-ancestry

high density lipoprotein cholesterol measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele G

OR 0.02

p 6.0e-13

N 450,015

Large GWAS

multi-ancestry

Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)

Allele G

OR 0.03

p 3.0e-11

N 928,679

Large GWAS

multi-ancestry

Richardson TG et al. “Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis.” Plos Medicine 17(3):e1003062 (2020)

Allele G

OR 0.02

p 9.0e-10

N 403,943

Large GWAS

European

polyunsaturated fatty acid measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele G

OR 0.02

p 7.0e-13

N 450,015

Large GWAS

multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

rs72805692

GWAS Catalog Trait Associations (20)

hemoglobin measurement

HbA1c measurement

lactate measurement

erythrocyte attribute

hematocrit

kell blood group glycoprotein measurement

lipoprotein measurement

sphingomyelin measurement

high density lipoprotein cholesterol measurement

polyunsaturated fatty acid measurement

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