rs7524102

This is a intergenic variant variant.

▶

GWAS Catalog Trait Associations (8)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

body height

Yengo L et al. “A saturated map of common genetic variants associated with human height.” Nature 610(7933):704-712 (2022)

Allele G

OR 0.01

p 3.0e-26

N 5,314,291

Large GWAS

European, Hispanic or Latin American, East Asian, African unspecified, South Asian

femoral neck bone mineral density

Pei YF et al. “Joint study of two genome-wide association meta-analyses identified 20p12.1 and 20q13.33 for bone mineral density.” Bone 110:378-385 (2018)

Allele A

OR 0.08

p 1.0e-20

N 40,491

Large GWAS

multi-ancestry

spine bone mineral density

Pei YF et al. “Joint study of two genome-wide association meta-analyses identified 20p12.1 and 20q13.33 for bone mineral density.” Bone 110:378-385 (2018)

Allele A

OR 0.09

p 5.0e-18

N 40,491

Large GWAS

multi-ancestry

bone tissue density

Styrkarsdottir U et al. “New sequence variants associated with bone mineral density.” Nature Genetics 41(1):15-7 (2009)

Allele A

OR 0.15

p 1.0e-16

N 6,865

Large GWAS

European

Rivadeneira F et al. “Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.” Nature Genetics 41(11):1199-206 (2009)

Allele A

OR 0.09

p 3.0e-10

N 19,195

Meta-analysisLarge GWAS

European

Styrkarsdottir U et al. “Multiple genetic loci for bone mineral density and fractures.” The New England Journal of Medicine 358(22):2355-65 (2008)

Allele A

OR 0.15

p 5.0e-16

N 5,861

Large GWAS

European

Dupuytren Contracture

Ng M et al. “A Genome-wide Association Study of Dupuytren Disease Reveals 17 Additional Variants Implicated in Fibrosis.” American Journal of Human Genetics 101(3):417-427 (2017)

Allele G

OR 1.35

p 3.0e-15

N 8,557

Large GWAS

multi-ancestry

Dolmans GH et al. “Wnt signaling and Dupuytren's disease.” The New England Journal of Medicine 365(4):307-17 (2011)

Allele G

OR 1.28

p 3.0e-9

N 3,692

Large GWAS

European

ulcerative colitis

Anderson CA et al. “Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.” Nature Genetics 43(3):246-52 (2011)

Allele A

OR 1.10

p 2.0e-13

N 26,405

Meta-analysisLarge GWAS

European

hemoglobin measurement

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele G

OR 0.01

p 1.0e-12

N 502,921

Large GWAS

multi-ancestry

hematocrit

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele G

OR 0.01

p 2.0e-11

N 503,490

Large GWAS

multi-ancestry

▶

Research that mentions this SNP (1)

▶

Replication study of candidate genes/loci associated with osteoporosis based on genome-wide screening

AssociationN=1,000Zhang YP et al.(2010)· Osteoporosis International

A replication study of 139 SNPs from three prior genome-wide association studies of bone mineral density in an independent sample of 1,000 unrelated US whites confirmed 38 SNPs (27% replication rate). Two SNPs achieved the most significant replication: rs3762397 in NR5A2 and rs3736228 in LRP5. Ten SNPs achieved combined p-values less than 3.6×10⁻⁴ across datasets, including rs3736228 (LRP5) with combined p=5.3×10⁻¹² for spinal BMD.

Traits studied:Bone mineral densityFemoral neck bone mineral density (FNBMD)Hip bone mineral density (HIPBMD)OsteoporosisSpinal bone mineral density (SPNBMD)

PubMed DOI Metascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

rs7524102

GWAS Catalog Trait Associations (8)

body height

femoral neck bone mineral density

spine bone mineral density

bone tissue density

Dupuytren Contracture

ulcerative colitis

hemoglobin measurement

hematocrit

Research that mentions this SNP (1)

Community Wiki

Comments