rs76344126

This is a regulatory region variant variant in the ARHGAP27 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

systolic blood pressure

Gurholt TP et al. “Large-scale brainstem neuroimaging and genetic analyses provide new insights into the neuronal mechanisms of hypertension.” Hgg Advances 6(1):100392 (2025)

Allele A

OR 6.16

p 7.0e-10

N 322,141

Large GWAS

European

About ARHGAP27

This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may pay a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2013]

View all ARHGAP27 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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