rs76854159

This variant is located in the TMEM106B gene.

▶

GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

major depressive disorder

Giannakopoulou O et al. “The Genetic Architecture of Depression in Individuals of East Asian Ancestry: A Genome-Wide Association Study.” Jama Psychiatry 78(11):1258-1269 (2021)

Allele A

OR 0.01

p 2.0e-9

N 694,747

Large GWAS

multi-ancestry

About TMEM106B

Enables ATPase binding activity. Involved in dendrite morphogenesis and lysosome localization. Located in endosome and lysosomal membrane. Implicated in hypomyelinating leukodystrophy 16. [provided by Alliance of Genome Resources, Jul 2025]

View all TMEM106B variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Loading comments…