TMEM106B

transmembrane protein 106B

Summary

Enables ATPase binding activity. Involved in dendrite morphogenesis and lysosome localization. Located in endosome and lysosomal membrane. Implicated in hypomyelinating leukodystrophy 16. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants108 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs1019307	7:12,251,790	G/C	regulatory region variant	—
rs6460895	7:12,252,540	C/T	—	—
rs12699323	7:12,253,362	T/G	—	—
rs2043539	7:12,253,880	G/A	5 prime UTR variant	—
rs759581407	7:12,254,447	C/G	—	likely benign
rs752498806	7:12,254,451	T/G	—	uncertain significance
rs2534902336	7:12,254,467	C/T	—	uncertain significance
rs2534902344	7:12,254,473	A/G	—	uncertain significance
rs2534902358	7:12,254,490	T/C	—	likely benign
rs1781655491	7:12,254,491	G/C	—	uncertain significance
rs1283609269	7:12,254,508	A/C	—	uncertain significance
rs1014945897	7:12,254,512	A/G	—	uncertain significance
rs748555916	7:12,254,527	G/C	—	uncertain significance
rs148896284	7:12,254,538	A/G	—	benign
rs760419159	7:12,254,545	A/G	—	likely benign
rs770339502	7:12,254,551	G/C	—	uncertain significance
rs143448984	7:12,254,552	A/T	—	likely benign
rs759330785	7:12,254,555	G/C	—	uncertain significance
rs137861973	7:12,254,564	G/C	—	uncertain significance
rs1201732402	7:12,254,577	G/T	—	uncertain significance
rs2534902548	7:12,254,578	T/C	—	uncertain significance
rs2534902553	7:12,254,582	C/T	—	uncertain significance
rs2534902558	7:12,254,585	A/G	—	uncertain significance
rs372931919	7:12,254,586	T/C	—	likely benign
rs1193564382	7:12,254,603	G/T	—	uncertain significance
rs2534902639	7:12,254,628	T/G	—	uncertain significance
rs1422211236	7:12,254,652	G/C	—	uncertain significance
rs778271556	7:12,254,654	G/C	—	uncertain significance
rs6460901	7:12,255,434	C/T	intron variant	—
rs6460902	7:12,255,511	G/A	intron variant	—
rs1180269819	7:12,258,068	C/T	—	likely benign
rs373068126	7:12,258,077	C/T	—	likely benign
rs759908498	7:12,258,085	G/A	—	likely benign
rs765398796	7:12,258,097	A/G	—	likely benign
rs3823612	7:12,258,755	G/C	intron variant	—
rs11974335	7:12,263,378	G/A	—	—
rs10950393	7:12,263,546	T/G	—	—
rs754476920	7:12,263,844	C/G	—	likely benign
rs1366784152	7:12,263,862	G/A	—	uncertain significance
rs2128525980	7:12,263,865	A/G	—	uncertain significance
rs1781850865	7:12,263,869	C/T	—	uncertain significance
rs1222975996	7:12,263,927	C/T	—	likely benign
rs766768609	7:12,263,933	C/A	—	likely benign
rs753522100	7:12,263,934	G/A	—	conflicting classifications of pathogenicity
rs144711908	7:12,263,936	C/T	—	likely benign
rs147889591	7:12,263,971	A/G	—	benign
rs1244141468	7:12,263,975	T/C	—	likely benign
rs147247575	7:12,263,989	G/A	—	conflicting classifications of pathogenicity
rs2534915440	7:12,264,016	G/T	—	uncertain significance
rs374949527	7:12,264,022	A/G	—	likely benign
rs113458466	7:12,264,026	A/G	—	likely benign
rs10950398	7:12,264,871	G/A	intron variant	—
rs76854159	7:12,265,059	A/C	—	—
rs6966915	7:12,265,988	C/T	intron variant	—
rs4721057	7:12,267,221	A/G	intron variant	—
rs4721059	7:12,267,495	G/T	—	—
rs4721061	7:12,267,559	G/C	intron variant	—
rs13229988	7:12,267,837	A/G	intron variant	—
rs5011434	7:12,268,717	C/T	intron variant	—
rs5011436	7:12,268,758	A/G	—	—
rs5011439	7:12,268,811	G/A	—	—
rs763685448	7:12,269,306	A/G	—	likely benign
rs1200294788	7:12,269,327	A/G	—	uncertain significance
rs201868191	7:12,269,343	C/G	—	benign
rs1252821877	7:12,269,344	G/A	—	uncertain significance
rs2534923502	7:12,269,350	G/C	—	uncertain significance
rs2534923523	7:12,269,371	C/T	—	uncertain significance
rs144597777	7:12,269,373	A/G	—	likely benign
rs2534923547	7:12,269,386	G/A	—	uncertain significance
rs775983188	7:12,269,406	A/C	—	benign
rs3173615	7:12,269,417	C/G	missense variant	benign
rs377719816	7:12,269,422	A/G	—	uncertain significance
rs2534923626	7:12,269,437	A/G	—	uncertain significance
rs1188352454	7:12,269,438	T/A	—	conflicting classifications of pathogenicity
rs2128527296	7:12,269,439	G/C	—	likely benign
rs750322595	7:12,269,445	A/G	—	uncertain significance
rs374151535	7:12,270,001	C/T	—	likely benign
rs376443768	7:12,270,008	C/T	—	likely benign
rs771468165	7:12,270,031	C/T	—	uncertain significance
rs367778603	7:12,270,035	C/T	—	likely benign
rs202102292	7:12,270,036	G/A	—	likely benign
rs1379680956	7:12,270,045	G/C	—	uncertain significance
rs374626555	7:12,270,082	A/G	—	likely benign
rs533927154	7:12,270,683	A/C	—	likely benign
rs1562709540	7:12,270,708	C/G	—	uncertain significance
rs1480577746	7:12,270,735	T/C	—	uncertain significance
rs2534925891	7:12,270,746	G/A	—	uncertain significance
rs2302634	7:12,270,770	T/A	—	benign
rs199499310	7:12,271,445	C/T	—	likely benign
rs3800842	7:12,271,452	A/G	—	benign
rs751214732	7:12,271,469	T/G	—	likely benign
rs2534927399	7:12,271,473	A/G	—	uncertain significance
rs1460309401	7:12,271,506	T/C	—	uncertain significance
rs373438435	7:12,271,529	C/T	—	likely benign
rs1554310600	7:12,271,530	G/A	—	pathogenic
rs151183990	7:12,271,553	T/C	—	benign
rs1037133993	7:12,271,557	T/A	—	likely benign
rs1399866980	7:12,271,560	G/A	—	uncertain significance
rs764463455	7:12,271,573	A/G	—	uncertain significance
rs2534927672	7:12,271,584	C/T	—	uncertain significance

Showing 100 of 108 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.