rs773111

This is a upstream gene variant variant in the RAB5B gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

level of gamma-aminobutyric acid receptor-associated protein in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele A

OR 0.06

p 1.0e-22

N 47,745

Large GWAS

European

Hashimoto's thyroiditis

White SL et al. “Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases.” Nature Genetics 58(2):307-316 (2026)

Allele A

OR 0.10

p 6.0e-13

N 1,420,658

Large GWAS

European

About RAB5B

Enables GDP binding activity; GTP-dependent protein binding activity; and GTPase activity. Involved in antigen processing and presentation and plasma membrane to endosome transport. Located in endosome and extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

View all RAB5B variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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