rs7791726
This is a downstream gene variant variant in the TMEM106B gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
frontotemporal dementia
Pottier C et al. “Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study.” The Lancet. Neurology 17(6):548-558 (2018)
Allele G
OR 2.00
p 2.0e-14
N 1,528
Large GWAS
European
About TMEM106B
Enables ATPase binding activity. Involved in dendrite morphogenesis and lysosome localization. Located in endosome and lysosomal membrane. Implicated in hypomyelinating leukodystrophy 16. [provided by Alliance of Genome Resources, Jul 2025]
View all TMEM106B variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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