rs7860457

This variant is located in the TTC39B gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

low density lipoprotein cholesterol measurement

Koskeridis F et al. “Pleiotropic genetic architecture and novel loci for C-reactive protein levels.” Nature Communications 13(1):6939 (2022)

Allele A

OR 0.01

p 2.0e-12

N 361,194

Large GWAS

European

polyunsaturated fatty acid measurement

Sun Y et al. “GWAS and multi-omics integrative analysis reveal novel loci and their molecular mechanisms for circulating fatty acids.” Hgg Advances 6(4):100470 (2025)

Allele G

OR —

p 5.0e-10

N 239,268

Large GWAS

European

About TTC39B

Predicted to be involved in several processes, including cholesterol homeostasis; negative regulation of cholesterol storage; and regulation of cholesterol efflux. [provided by Alliance of Genome Resources, Jul 2025]

View all TTC39B variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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