rs802734

This genome-wide association study identified two regions associated with age at diagnosis (AAD) of type 1 diabetes using ImmunoChip data from 15,696 cases: the MHC region (lead SNP rs9273363, p=2.16×10⁻³⁵) and the 6q22.33 region (lead SNP rs72975913, p=2.94×10⁻¹⁰, near PTPRK and THEMIS genes). The 6q22.33 region showed stronger association with early-onset type 1 diabetes (diagnosed <5 years, OR=0.78 for rs72975913), with a combined effect of 4.12 years younger diagnosis in homozygous carriers of both risk alleles.

This meta-analysis of 22,233 CAD cases and 64,762 controls tested 41 celiac disease-associated SNPs for association with coronary artery disease (CAD). While 58.5% of celiac disease risk alleles showed positive association with CAD (OR 1.001-1.081), this was not significantly different from the 50% expected by chance (p=0.069). Only rs653178 at the SH2B3/ATXN2 locus achieved study-wide statistical significance (OR 1.081, p=2.2×10⁻⁶), likely through pleiotropic effects. The findings provide no convincing evidence that genetic variants associated with celiac disease contribute to CAD risk.

This meta-analysis of 7 genome-wide association studies identified three novel multiple sclerosis susceptibility loci: rs170934 near EOMES (3p24.1, OR=1.17, P=1.6×10⁻⁸), rs2150702 in MLANA (9p24.1, OR=1.16, P=3.3×10⁻⁸), and rs6718520 near THADA (2p21, OR=1.17, P=3.4×10⁻⁸). The analysis encompassed 5,545 cases and 12,153 controls and identified 10 additional loci with suggestive evidence of association (P<1×10⁻⁶), including IL12B, TAGAP, PLEK, and ZMIZ1, which are shared with other inflammatory diseases.