rs8067378

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

systemic lupus erythematosus

Khunsriraksakul C et al. “Multi-ancestry and multi-trait genome-wide association meta-analyses inform clinical risk prediction for systemic lupus erythematosus.” Nature Communications 14(1):668 (2023)
Allele A
OR 0.08
p 5.0e-23
N 718,496
Large GWAS
multi-ancestry

primary biliary cirrhosis

Liu JZ et al. “Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis.” Nature Genetics 44(10):1137-41 (2012)
Allele G
OR 1.26
p 6.0e-14
N 11,375
Large GWAS
European

cervical carcinoma

Shi Y et al. “A genome-wide association study identifies two new cervical cancer susceptibility loci at 4q12 and 17q12.” Nature Genetics 45(8):918-22 (2013)
Allele G
OR 1.19
p 9.0e-10
N 4,392
Large GWAS
East Asian
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Research that mentions this SNP (2)

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Genome‐wide association study of HPV‐associated cervical cancer in Japanese women
AssociationN=412Kiyonori Miura et al.(2014)· Journal of Medical Virology

A genome-wide association study (GWAS) of 226 Japanese women with cervical cancer and 186 controls identified 89 SNPs with p-value < 10^-4, including rs997363 (p=1.23×10^-6, OR=1.99), rs7780883 (p=2.49×10^-6, OR=3.28), and rs6726538 (p=2.76×10^-6, OR=0.52), but no SNPs met genome-wide significance threshold after multiple-testing correction. Two SNPs, rs621310 and rs11653282, showed weak associations in replication analysis. The study suggests that HPV-associated cervical cancer susceptibility in Japanese women may involve multiple genetic variants with small individual effects, or that larger sample sizes are needed to detect true associations.

Traits studied:Cervical cancer susceptibilityHPV persistenceUterine cervical cancer
PubMedDOIMetascience Observatory
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Allergy and glioma risk: Test of association by genotype
AssociationN=5,548Sara E. Dobbins et al.(2011)· International Journal of Cancer

Case-control genome-wide association study of 1,878 glioma cases and 3,670 controls examining associations between asthma/allergy susceptibility variants and glioma risk. SNP rs7216389 at 17q21 (ORMDL3) was significantly associated with increased glioma risk (OR=1.10, 95% CI: 1.01-1.19, P=0.022), providing genetic evidence for a positive association between asthma susceptibility and glioma risk, contrary to epidemiological studies reporting inverse associations.

Traits studied:AsthmaAtopic dermatitisAtopy/AllergyEczemaEosinophil countGliomaIgE levels
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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